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| Content Provider | frontiers |
|---|---|
| Author | Heinzel, Andreas Schrezenmeier, Eva Regele, Florina Hu, Karin Raab, Lukas Eder, Michael Aigner, Christof Jabbour, Rhea Aschauer, Constantin Stefanski, Ana-Luisa Dörner, Thomas Budde, Klemens Reindl-Schwaighofer, Roman Oberbauer, Rainer |
| Abstract | AbstractResponse to SARS-CoV-2-vaccines in kidney-transplant recipients (KTR) is severely reduced. Heterologous3rd vaccination combining mRNA and vector vaccines did not increase seroconversion at 4 weeks after vaccination, but evolution of antibody levels beyond the first month remains unknown. We have recently completed a randomized-controlled trial on heterologous (Ad26COVS1) vs. homologous (BNT162b2 or mRNA-1273) 3rd vaccination in 201 KTR not developing SARS-CoV-2-spike-protein antibodies following two doses of mRNA vaccine (EurdraCT: 2021-002927-39). Here, we report seroconversion at the second follow-up at 3 months after the 3rd vaccination (prespecified secondary endpoint). In addition, higher cut-off levels associated with neutralizing capacity and protective immunity were applied (i.e., > 15, > 100, > 141, and > 264 BAU/ml). A total of 169 patients were available for the 3-month follow-up. Overall, seroconversion at 3 months was similar between both groups (45 vs. 50% for mRNA and the vector group, respectively; p = 0.539). However, when applying higher cut-off levels, a significantly larger number of individuals in the vector group reached antibody levels > 141 and > 264 BAU/ml at the 3-month follow-up (141 BAU/ml: 4 vs. 15%, p = 0.009 and 264 BAU/ml: 1 vs. 10%, p = 0.018 for mRNA vs. the vector vaccine group, respectively). In line, antibody levels in seroconverted patients further increased from month 1 to month 3 in the vector group while remaining unchanged ... |
| ISSN | 2296858X |
| DOI | 10.3389/fmed.2022.1048395 |
| Volume Number | 9 |
| Journal | Frontiers in Medicine |
| Language | English |
| Publisher Date | 2022-10-10 |
| Access Restriction | Open |
| Subject Keyword | COVID-19 Kidney transplanation COVID-19 vaccination Third vaccination Heterologous vaccination |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine |
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