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| Content Provider | frontiers |
|---|---|
| Author | Shrestha Palikhe, Nami Mackenzie, Constance A. Licskai, Christopher Kim, Richard B. Vliagoftis, Harissios Cameron, Lisa |
| Description | BackgroundCRTh2 is G protein coupled receptor for prostaglandin D2 (PGD)2 expressed by immune cells that drive type 2 inflammation such as CD4+ T cells (Th2), eosinophils and group 2 innate lymphoid cells (ILC2) as well as structural cells including smooth muscle and epithelium. CRTh2-expressing cells are increased in the blood and airways of asthmatics and severe asthma is characterized by increased activity of the PGD2-CRTh2 pathway. The CRTh2 single nucleotide polymorphism (SNP) rs533116 G > A is associated with development of asthma and increased Th2 cell differentiation.ObjectiveTo examine whether CRTh2 rs533116G > A associates with asthma severity. Since severe asthma is more common in females than males, we performed a sex-stratified analysis.MethodsClinical data from asthmatics (n = 170) were obtained from clinic visits and chart review. Asthma severity was assessed according to ERS/ATS guidelines. Peripheral blood cells were characterized by flow cytometry and qRT-PCR. Genotyping was performed by TaqMan assay.ResultsOlder females (≥45 years) homozygous for minor A allele of rs533116 were more likely to have severe asthma, lower FEV1, a higher prescribed dose of inhaled corticosteroid and more type 2 inflammation than females carrying GA or GG genotypes. Comparing females and males with the AA genotype also revealed that women had more type 2 inflammation.Conclusions and significanceThe polymorphism CRTh2 rs533116 G > A associates with severe asthma and type 2 infl... |
| Abstract | CRTh2 is G protein coupled receptor for prostaglandin D2 (PGD)2 expressed by immune cells that drive type 2 inflammation such as CD4+ T cells (Th2), eosinophils and group 2 innate lymphoid cells (ILC2) as well as structural cells including smooth muscle and epithelium. CRTh2-expressing cells are increased in the blood and airways of asthmatics and severe asthma is characterized by increased activity of the PGD2-CRTh2 pathway. The CRTh2 single nucleotide polymorphism (SNP) rs533116 G>A is associated with development of asthma and increased Th2 cell differentiation. To examine whether CRTh2 rs533116G>A associates with asthma severity. Since severe asthma is more common in females than males, we performed a sex-stratified analysis. Clinical data from asthmatics (n=170) were obtained from clinic visits and chart review. Asthma severity was assessed according to ERS/ATS guidelines. Peripheral blood cells were characterized by flow cytometry and qRT-PCR. Genotyping was performed by TaqMan assay. Results Older females (≥ 45 years) homozygous for minor A allele of rs533116 were more likely to have severe asthma, lower FEV1, a higher prescribed dose of inhaled corticosteroid and more type 2 inflammation than females carrying GA or GG genotypes. Comparing females and males with the AA genotype also revealed that women had more type 2 inflammation. The polymorphism CRTh2 rs533116 G>A associates with severe asthma and type 2 inflammation in older females. This study reveals a gene-sex-aging interaction influencing the effect of CRTh2 on asthma severity. |
| ISSN | 2296858X |
| DOI | 10.3389/fmed.2022.970495 |
| Volume Number | 9 |
| Journal | Frontiers in Medicine |
| Language | English |
| Publisher Date | 2022-10-13 |
| Access Restriction | Open |
| Subject Keyword | Female Genetic Variation Sex difference CRTH2 Polymorphism Type 2 inflammation Asthma severity |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine |
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