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| Content Provider | frontiers |
|---|---|
| Author | Li, Guo-Hua Huang, Ke Dong, Guan-Ping Zhang, Jian-Wei Gong, Chun-Xiu Luo, Fei-Hong Luo, Xiao-Ping Wang, Chun-Lin Zhu, Min Li, Pin Wang, Ling Fu, Jun-Fen |
| Organization | The T1DM China Study Group for Children Adolescents |
| Abstract | ObjectiveTo investigate the clinical incidence and characteristics of type 1 diabetes mellitus (T1DM) of children and adolescents at the time of initial diagnosis in China.MethodsData on all pediatric patients with newly diagnosed T1DM were retrospectively collected from 34 medical centers in 25 major cities in China from January 2015 to January 2020. Patients were classified into three age groups: <5 years, 5 to <10 years, and ≥10 years of age. The same patient population was also categorized into diabetic ketoacidosis (DKA) and non-DKA groups based on clinical criteria.ResultsThe mean annual clinical incidence of T1DM was 3.16/100,000 from the years 2015 to 2019. A total of 6,544 patients with newly diagnosed T1DM aged 0–16 years (median 7.84 ± 3.8) were studied [ages <5 years (29.3%), 5 to <10 years (38.7%), and ≥10 years (32%)], 52.4% of them were women. In total, 90.5% of the cases were occurred in individuals without a family history. Patients had lower C-peptide (CP) and body mass index (BMI) z scores when compared with healthy children, 41.8% of them had measurable T1DM-related antibodies and 52.7% had DKA. Among all three age groups, the <5 years group had the lowest BMI z score, CP, and glycated hemoglobin (HbA1c) on average, while it had the highest incidence rate of DKA (56.9%). Compared to the non-DKA group, the DKA group was significantly younger, with a lower BMI z score and CP, higher antibody positive rate, HbA1c, and the rate of insulin pump therapy.Concl... |
| ISSN | 22962360 |
| DOI | 10.3389/fped.2022.888370 |
| Volume Number | 10 |
| Journal | Frontiers in Pediatrics |
| Language | English |
| Publisher Date | 2022-06-15 |
| Access Restriction | Open |
| Subject Keyword | Diabetic Ketoacidosis Typ 1 diabetes Incidence Β-cell function Children and adolescences |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pediatrics, Perinatology and Child Health |
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