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| Content Provider | frontiers |
|---|---|
| Author | Lin, Liang-Mei Chang, Yu-Jun Yang, Kuender D. Lin, Ching-Hsiung Chien, Jien-Wen Kao, Jun-Kai Lee, Ming-Sheng Chiang, Tsay-I Lin, Ching-Yuang Tsai, Yi-Giien |
| Description | BackgroundImpulse oscillometry (IOS) and fractional exhaled nitric oxide (FeNO) are sensitive and non-invasive methods to measure airway resistance and inflammation, although there are limited population-based studies using IOS and FeNO to predict asthma control.ObjectiveThis study aimed to investigate the utility of IOS and FeNO for assessing childhood asthma control in terms of small airway dysfunction and airway inflammation.MethodsThis prospective observational cohort study enrolled 5,018 school children (aged 6–12 years), including 560 asthmatic children and 140 normal participants. FeNO, spirometry, IOS, bronchial dilation test, total IgE, and childhood asthma control test (C-ACT) were measured. FeNO, IOS, spirometry, and C-ACT results were correlated with childhood asthma with and without control.ResultsUncontrolled asthmatic children had abnormal FeNO, IOS, and spirometric values compared with control subjects (P < 0.05). IOS parameters with R5, R5-R20, X5, Ax, △R5, and FeNO can predict lower C-ACT scales by the areas under receiver operating characteristic curves (AUCs) (0.616, 0.625, 0.609, 0.622, 0.625, and 0.714). A combination of FeNO (>20 ppb) with IOS measure significantly increased the specificity for predicting uncontrolled asthma patients compared with FeNO alone (P < 0.01). A multiple regression model showed that small airway parameter (R5-R20) was the strongest risk factor [OR (95% CI): 87.26 (7.67–993.31)] for uncontrolled asthma patients. Poor control... |
| Abstract | BACKGROUND: Impulse oscillometry (IOS) and fractional exhaled nitric oxide (FeNO) are sensitive, and non-invasive methods to measure airway resistance and inflammation, though there are limited population-based studies using IOS and FeNO to predict asthma control. OBJECTIVE: To investigate the utility of IOS and FeNO for assessing childhood asthma control in terms of small airway dysfunction and airway inflammation. METHODS: This prospective observational cohort study enrolled 5018 school children (6-12 years old), including 560 asthmatic children and 140 normal participants. FeNO, spirometry, IOS, bronchial dilation test, total IgE, and childhood asthma control test (C-ACT) were measured. FeNO, IOS, spirometry, and C-ACT results were correlated to childhood asthma with and without control. RESULTS: Uncontrolled asthmatic children had abnormal FeNO, IOS, and spirometric values compared to control subjects (P 20 ppb) with IOS measure significantly increased the specificity for predicting uncontrolled asthma patients compared to FeNO alone (P < 0.01). A multiple regression model showed that small airway parameter (R5-R20) was the strongest risk factor [OR (95% CI): 87.26 (7.67-993.31)] for uncontrolled asthma patients. Poor control with lower C-ACT scales correlated with high FeNO (r = -0.394), R5 (r = -0.106) and R5-R20 (r = -0.129) in asthmatic children (P < 0.05). CONCLUSIONS: A combined use of FeNO and IOS measurements strongly predicts childhood asthma with or without control. |
| ISSN | 22962360 |
| DOI | 10.3389/fped.2022.877681 |
| Volume Number | 10 |
| Journal | Frontiers in Pediatrics |
| Language | English |
| Publisher Date | 2022-06-17 |
| Access Restriction | Open |
| Subject Keyword | Asthma control 3 Pulmonary Function Fractional exhaled nitric oxide Allergic Asthma Impulse oscillometry |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pediatrics, Perinatology and Child Health |
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