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| Content Provider | frontiers |
|---|---|
| Author | El-Khateeb, Eman El-Berri, Eman I. Mosalam, Esraa M. Nooh, Mohamed Z. Abdelsattar, Shimaa Alghamdi, Amira M. Alrubia, Sarah Abdallah, Mahmoud S. |
| Abstract | Background: Type 2 diabetes mellitus (T2DM) is common with obesity. Metformin is a first line therapy for this condition. However, it had only a minor impact on weight loss in some patients. Aim: This study aimed to evaluate the effectiveness, tolerability, and safety of montelukast add-on therapy to metformin in obese diabetic patients. Methods: One hundred obese diabetic adult patients were recruited and randomized into two equal groups. group1; received placebo plus metformin 2g/d and group2; received 2g/d metformin plus 10 mg/d montelukast. Demographic, anthropometric measurements (e.g., body weight, body mass index (BMI) and visceral adiposity index), lipid profile, diabetes-control measures (fasting blood glucose, glycated hemoglobin (HbA1c), and homeostatic model assessment for Insulin Resistance (HOMA-IR)), adiponectin, and inflammatory markers (e.g., TNF-α, IL-6, and leukotriene B4) were assessed and reported for each group at the baseline and after 12 weeks of treatment. Results: Both interventions significantly reduced all the measured parameters except adiponectin and HDL-C where the levels increased compared to baseline data (p<0.001). Montelukast group significantly improved all parameters compared to the placebo group (ANCOVA test p<0.001). The % changes in BMI, HbA1c, HOMA-IR, and inflammatory markers were 5%, 9%, 41%, and 5-30%, respectively in the placebo group compared to 8%, 16%, 58%, and 50-70%, respectively in the montelukast group. Conclusion: Montelukast adjuvant therapy was superior to metformin sole therapy in diabetes control and weight loss, most likely due to increased insulin sensitivity and anti-inflammatory properties. The combination was tolerable and safe within the study duration. Clinical Trial Registration: Clinicaltrial.gov (NCT04075110). |
| ISSN | 16639812 |
| DOI | 10.3389/fphar.2023.1153653 |
| Volume Number | 14 |
| Journal | Frontiers in Pharmacology |
| Language | English |
| Publisher Date | 2023-04-11 |
| Access Restriction | Open |
| Subject Keyword | Montelukast Leukotriene receptor antagonist Metformin Obesity T2DM |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pharmacology Pharmacology (medical) |
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