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| Content Provider | frontiers |
|---|---|
| Author | Bosseboeuf, Adrien Seillier, Célia Mennesson, Nicolas Allain-Maillet, Sophie Fourny, Maeva Tallet, Anne Piver, Eric Lehours, Philippe Mégraud, Francis Berthelot, Laureline Harb, Jean Bigot-Corbel, Edith Hermouet, Sylvie |
| Abstract | Previous studies showed that monoclonal immunoglobulins G (IgGs) of "monoclonal gammopathy of undetermined significance" (MGUS) and myeloma were hyposialylated, thus presumably pro-inflammatory, and for about half of patients, the target of the monoclonal IgG was either a virus –Epstein-Barr virus (EBV), other herpes viruses, hepatitis C virus (HCV)– or a glucolipid, lysoglucosylceramide (LGL1), suggesting antigen-driven disease in these patients. In the present study, we show that monoclonal IgAs share these characteristics. We collected 35 sera of patients with a monoclonal IgA (6 MGUS, 29 myeloma) and we were able to purify 25 of the 35 monoclonal IgAs (6 MGUS, 19 myeloma). Monoclonal IgAs from MGUS and myeloma patients were significantly less sialylated than IgAs from healthy volunteers. When purified monoclonal IgAs were tested against infectious pathogens and LGL1, five myeloma patients had a monoclonal IgA that specifically recognized viral proteins: the core protein of HCV in one case, EBV nuclear antigen 1 (EBNA-1) in four cases (21.1% of IgA myeloma). Monoclonal IgAs from three myeloma patients reacted against LGL1. In summary, monoclonal IgAs are hyposialylated and as described for IgG myeloma, significant subsets (8/19, or 42%) of patients with IgA myeloma may have viral or self (LGL1) antigen-driven disease. |
| ISSN | 16643224 |
| DOI | 10.3389/fimmu.2020.00854 |
| Volume Number | 11 |
| Journal | Frontiers in Immunology |
| Language | English |
| Publisher Date | 2020-05-27 |
| Access Restriction | Open |
| Subject Keyword | Glycosylation Number of lines: 956 Epstein-Barr virus Hepatitis C virus Immunoglobulin A (Ig A) Epstein-Barr virus nuclear antigen 1 Multiple Myeloma Monoclonal immunoglobulin specificity Monoclonal gammopathy of undetermined significance (MGUS) Infectious antigens Lysoglucosylceramide (LGL-1) Sialylation Number of pages: 26 monoclonal immunoglobulin specificity lysoglucosylceramide (LGL-1) sialylation Number of pages: 26 |
| Content Type | Text |
| Resource Type | Article |
| Subject | Immunology and Allergy Immunology |
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