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| Content Provider | frontiers |
|---|---|
| Author | Leng, Xin She, Mengyao Jin, Xilang Chen, Jiao Ma, Xuehao Chen, Fulin Li, Jianli Yang, Bingqin |
| Abstract | Copper is a vital trace metal in human body, which plays the significant roles in amounts of physiological and pathological processes. The application of copper-selective probe has attracted great interests from environmental tests to life process research, yet a few of sensitive Cu2+ tests based on on-site analysis have been reported. In this paper, a novel fluorescein-based fluorescent probe N4 was designed, synthesized, and characterized, which exhibited high selectivity and sensitivity to Cu2+ comparing with other metal ions in ethanol–water (1/1, v/v) solution. The probe N4 bonded with Cu2+ to facilitate the ring-opening, and an obvious new band at 525 nm in the fluorescence spectroscopy appeared, which could be used for naked-eye detection of Cu2+ within a broad pH range of 6–9. Meanwhile, a good linearity between the fluorescence intensity and the concentrations of Cu2+ ranged 0.1–1.5 eq. was observed, and the limit of detection of N4 to Cu2+ was calculated to be as low as 1.20 μm. In addition, the interaction mode between N4 and Cu2+ was found to be 1:1 by the Job's plot and mass experiment. Biological experiments showed that the probe N4 exhibited low biological toxicity and could be applied for Cu2+ imaging in living cells. The significant color shift associated with the production of the N4-Cu2+ complex at low micromolar concentrations under UV light endows N4 with a promising probe for field testing of trace Cu2+ ions. |
| ISSN | 2296861X |
| DOI | 10.3389/fnut.2022.932826 |
| Volume Number | 9 |
| Journal | Frontiers in Nutrition |
| Language | English |
| Publisher Date | 2022-06-27 |
| Access Restriction | Open |
| Subject Keyword | Copper ion Test strips Fluorescent probe Cells imaging Trace metal |
| Content Type | Text |
| Resource Type | Article |
| Subject | Nutrition and Dietetics Endocrinology, Diabetes and Metabolism Food Science |
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