Please wait, while we are loading the content...
Please wait, while we are loading the content...
| Content Provider | frontiers |
|---|---|
| Author | Cheng, Kai-Hung Lin, Jr-Rung Anderson, Craig S. Lai, Wen-Ter Lee, Tsong-Hai Chang, Yeu-Jhy Chang, Chien-Hung Wu, Hsiu-Chuan Huang, Kuo-Lun Chang, Ting-Yu Liu, Chi-Hung Cheng, Chih-Kuang Chiu, Te-Fa Huang, Chi-Ren Wong, Ho-Fai Toh, Cheng-Hong Peng, Tsung-I Huang, Wen-Yi Chien, Yu-Yi Chung, Kong Lo, Hsiang-Yun Chen, Yao-Liang Lee, Jiann-Der Lee, Meng Huang, Yen-Chu Chou, Shao-Wen Hsiao, Cheng-Ting Tsai, Yuan-Hsiung Liou, Chia-Wei Chang, Ku-Chou Lin, Hung-Sheng Tan, Teng-Yeow Fu, Ru-Huei Hsi Chen, Wei Kung, Chia-Te Lin, Wei-Che |
| Abstract | Background– Low lipid level is associated with better cardiovascular outcome. However, lipid paradox indicating low lipid level has worse outcome can be seen under acute injury in some diseases. The present study was designed to clarify the prognostic significance of acute-phase lipid levels within 1 day after admission for stroke on mortality in first-ever, statin-naïve acute ischemic (IS) and hemorrhagic stroke (HS). Methods– This observational study was conducted using the data from Stroke Registry In Chang-Gung Healthcare System (SRICHS) between 2009 and 2012. Patients with recurrent stroke, onset of symptoms >1 day and history of lipid-lowering agents prior to index stroke were excluded. Stroke was classified into IS and hypertension-related HS. The primary outcomes were 30-day and 1-year mortality identified by linkage to national death registry for date and cause of death. Receiver operating characteristic curve analysis and multivariate Cox proportional hazard models were used to examine the association of admission lipids with mortality. Results– Among 18,268 admitted stroke patients, 3,746 IS and 465 HS were eligible for analysis. In IS, total cholesterol (TC) <163.5mg/dL, triglyceride (TG) <94.5mg/dL, low-density lipoprotein (LDL) <100mg/dL, non-high-density lipoprotein cholesterol (non-HDL-C) <130.5mg/dL and TC/HDL ratio <4.06 had significantly higher risk for 30-day/1-year mortality with hazard ratio (HR) of 2.05/1.37, 1.65/1.31, 1.68/1.38, 1.80/1.41 and 1.58/1.38, respectively, compared to high TC, TG, LDL, non-HDL-C and TC/HDL ratio (all p<0.01). In HS, lipid profiles were not associated with mortality, except HDL for 30-day mortality (p=0.025) and high uric acid concentrations for 30-day and 1-year mortality (p=0.002, 0.012, respectively). High fasting glucose and high NIHSS score at admission were associated with higher 30-day and 1-year mortality in both IS and HS and low blood pressure only in IS (p<0.05). Synergic effects on mortality were found when low lipids were incorporating with high fasting glucose, low blood pressure and high NIHSS score in IS (p<0.05). Conclusions- Lipid paradox showing low acute-phase lipid levels with high mortality could be seen in statin-naïve acute IS but not HS. The mortality in IS was increased when low lipids were incorporating with high fasting glucose, low blood pressure and high NIHSS score. |
| ISSN | 16642295 |
| DOI | 10.3389/fneur.2018.00541 |
| Volume Number | 9 |
| Journal | Frontiers in Neurology |
| Language | English |
| Publisher Date | 2018-08-29 |
| Access Restriction | Open |
| Subject Keyword | Outcome Intracerebral hemorrhage Ischemic stroke Lipids Mortality |
| Content Type | Text |
| Resource Type | Article |
| Subject | Neurology Neurology (clinical) |
National Digital Library of India (NDLI) is a virtual repository of learning resources which is not just a repository with search/browse facilities but provides a host of services for the learner community. It is sponsored and mentored by Ministry of Education, Government of India, through its National Mission on Education through Information and Communication Technology (NMEICT). Filtered and federated searching is employed to facilitate focused searching so that learners can find the right resource with least effort and in minimum time. NDLI provides user group-specific services such as Examination Preparatory for School and College students and job aspirants. Services for Researchers and general learners are also provided. NDLI is designed to hold content of any language and provides interface support for 10 most widely used Indian languages. It is built to provide support for all academic levels including researchers and life-long learners, all disciplines, all popular forms of access devices and differently-abled learners. It is designed to enable people to learn and prepare from best practices from all over the world and to facilitate researchers to perform inter-linked exploration from multiple sources. It is developed, operated and maintained from Indian Institute of Technology Kharagpur.
Learn more about this project from here.
NDLI is a conglomeration of freely available or institutionally contributed or donated or publisher managed contents. Almost all these contents are hosted and accessed from respective sources. The responsibility for authenticity, relevance, completeness, accuracy, reliability and suitability of these contents rests with the respective organization and NDLI has no responsibility or liability for these. Every effort is made to keep the NDLI portal up and running smoothly unless there are some unavoidable technical issues.
Ministry of Education, through its National Mission on Education through Information and Communication Technology (NMEICT), has sponsored and funded the National Digital Library of India (NDLI) project.
| Sl. | Authority | Responsibilities | Communication Details |
|---|---|---|---|
| 1 | Ministry of Education (GoI), Department of Higher Education |
Sanctioning Authority | https://www.education.gov.in/ict-initiatives |
| 2 | Indian Institute of Technology Kharagpur | Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project | https://www.iitkgp.ac.in |
| 3 | National Digital Library of India Office, Indian Institute of Technology Kharagpur | The administrative and infrastructural headquarters of the project | Dr. B. Sutradhar bsutra@ndl.gov.in |
| 4 | Project PI / Joint PI | Principal Investigator and Joint Principal Investigators of the project |
Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon |
| 5 | Website/Portal (Helpdesk) | Queries regarding NDLI and its services | support@ndl.gov.in |
| 6 | Contents and Copyright Issues | Queries related to content curation and copyright issues | content@ndl.gov.in |
| 7 | National Digital Library of India Club (NDLI Club) | Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach | clubsupport@ndl.gov.in |
| 8 | Digital Preservation Centre (DPC) | Assistance with digitizing and archiving copyright-free printed books | dpc@ndl.gov.in |
| 9 | IDR Setup or Support | Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops | idr@ndl.gov.in |
|
Loading...
|