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| Content Provider | frontiers |
|---|---|
| Author | Chen, Chen Gao, Feng-Hou |
| Description | Progressively infiltrating of immune cells are associated with the progression of melanoma. Especially, Th17 cells in melanoma microenvironment have both antitumor and protumor effects. It is necessary to understand the contradictory data of how Th17 cells play a role in melanoma. This review will summarize the current knowledge regarding the potential mechanisms that may be involved in the effects of Th17 cells in melanoma progression. Currently, since adoptive transferring Th17 cells has made great success in eradicating melanoma in mice, it becomes the primary strategy that the enriching stemness-like memory Th17 cells by adding distinct cytokines or pharmacologic reagents augment Th17 cells expansion ex vivo and enhance antitumor effect in next-generation trials and its clinical implications. |
| Abstract | The progressive infiltration of immune cells is associated with the progression of melanoma. Specifically, Th17 cells in melanoma microenvironment have both antitumor and protumor effects. It is now necessary to understand the contradictory data associated with how Th17 cells play a role in melanoma. This review will summarize the current knowledge regarding the potential mechanisms that may be involved in the effects of Th17 cells in melanoma progression. Currently, since adoptive transferring Th17 cells has been successful in eradicating melanoma in mice, it offers promise for next-generation adoptive cell transfer, as ex vivo expanded stemness-like memory Th17 cells which are induced by distinct cytokines or pharmacologic reagents may be infused into melanoma patients to potentiate treatment outcome. |
| ISSN | 16643224 |
| DOI | 10.3389/fimmu.2019.00187 |
| Volume Number | 10 |
| Journal | Frontiers in Immunology |
| Language | English |
| Publisher Date | 2019-02-08 |
| Access Restriction | Open |
| Subject Keyword | Adoptive cell transfer Melanoma Tumor Microenvironment Th17 cell Immunotherapy |
| Content Type | Text |
| Resource Type | Article |
| Subject | Immunology and Allergy Immunology |
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