NDLI: Enhancing adoptive T cell immunotherapy with microRNA therapeutics

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Enhancing adoptive T cell immunotherapy with microRNA therapeutics

Content Provider	Scilit
Author	Ji, Yun Hocker, James D. Gattinoni, Luca
Copyright Year	2016
Description	Journal: Seminars in Immunology Adoptive T cell-based immunotherapies can mediate complete and durable regressions in patients with advanced cancer, but current response rates remain inadequate. Maneuvers to improve the fitness and antitumor efficacy of transferred T cells have been under extensive exploration in the field. Small non-coding microRNAs have emerged as critical modulators of immune system homeostasis and T cell immunity. Here, we summarize recent advances in our understanding of the role of microRNAs in regulating T cell activation, differentiation, and function. We also discuss how microRNA therapeutics could be employed to fine-tune T cell receptor signaling and enhance T cell persistence and effector functions, paving the way for the next generation of adoptive immunotherapies.
Related Links	http://europepmc.org/articles/pmc4862908?pdf=render https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4862908/pdf
Ending Page	53
Page Count	9
Starting Page	45
ISSN	10445323
e-ISSN	10963618
DOI	10.1016/j.smim.2015.11.006
Journal	Seminars in Immunology
Issue Number	1
Volume Number	28
Language	English
Publisher	Elsevier BV
Publisher Date	2016-02-01
Access Restriction	Open
Subject Keyword	Journal: Seminars in Immunology Research and Experimental Medicine Adoptive Cell Transfer Cd8(+) T Cells Microrna (mirna) T Cell Differentiation Tumor Immunotherapy
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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