NDLI: Adipocyte Ceramides—The Nexus of Inflammation and Metabolic Disease

Content Provider	frontiers
Author	Chaurasia, Bhagirath Talbot, Chad Lamar Summers, Scott A.
Abstract	Adipose depots are heterogeneous tissues that store and sense fuel levels. Through the secretion of lipids, cytokines, and protein hormones (adipokines), they communicate with other organ systems, informing them of the organism's nutritional status. The adipose tissues include diverse types of adipocytes (white, beige, and brown) distinguished by the number/size of lipid droplets, mitochondrial density, and thermogenic capacity. Moreover, they include a spectrum of immune cells that modulate metabolic activity and tissue remodeling. The unique characteristics and interplay of these cells control the production of ceramides, a class of nutrient signals derived from fat and protein metabolism that modulate adipocyte function to regulate glucose and lipid metabolism. The excessive accumulation of ceramides contributes to the adipose tissue inflammation and dysfunction that underlies cardiometabolic disease. Herein we review findings on this important class of lipid species and discuss their role at the convergence point that links overnutrition/inflammation to key features of the metabolic syndrome.
ISSN	16643224
DOI	10.3389/fimmu.2020.576347
Volume Number	11
Journal	Frontiers in Immunology
Language	English
Publisher Date	2020-09-23
Access Restriction	Open
Subject Keyword	Inflammation Ceramide Insulin Diabetes Adipocyte
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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Adipocyte Ceramides—The Nexus of Inflammation and Metabolic Disease