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Chemical Constituents from Streblus taxoides Wood with Their Antibacterial and Antityrosinase Activities Plus in Silico Study.
| Content Provider | Europe PMC |
|---|---|
| Author | Parndaeng, Kedsaraporn Pitakbut, Thanet Wattanapiromsakul, Chatchai Hwang, Jae Sung Udomuksorn, Wandee Dej-adisai, Sukanya |
| Editor | Luna-Herrera, Julieta Jimenez Arellanes, María Adelina |
| Copyright Year | 2023 |
| Abstract | Hyperpigmentation frequently occurs after inflammation from bacterial infection. Thus, the inhibition activity of tyrosinase, the key enzyme to catalyze the melanogenesis and/or inhibition of bacterial infection, could decrease melanin production. Hence, the potential inhibitors could be discovered from natural products. ω-Hydroxymoracin C (1), a new compound with two other 2-arylbenzofurans, i.e., moracin M (2) and moracin C (3), and two stilbenes, i.e., 3, 4, 3’, 5′-tetrahydroxybibenzyl (4) and piceatannol (5), were isolated from the wood of Streblus taxoides. Compound 4 showed a strong inhibitory activity against tyrosinase enzyme with an IC50 value of 35.65 µg/mL, followed by compound 2 with an IC50 value of 47.34 µg/mL. Conversely, compound 1, 3 and 5 showed moderate activity, with IC50 values of 109.64, 128.67 and 149.73 µg/mL, respectively. Moreover, compound 1 and 3 showed an antibacterial effect against some Staphylococcus spp. Thus, the isolated compounds exhibited potential antityrosine and antibacterial effects. Additionally, an in silico study was performed in order to predict theoretical molecular interactions between the obtained metabolites from S. taxoides and tyrosinase as an extended in vitro enzyme binding assay experiment. |
| Journal | Antibiotics (Basel, Switzerland) |
| Volume Number | 12 |
| PubMed Central reference number | PMC9952338 |
| Issue Number | 2 |
| PubMed reference number | 36830230 |
| e-ISSN | 20796382 |
| DOI | 10.3390/antibiotics12020319 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2023-02-03 |
| Access Restriction | Open |
| Rights License | Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). © 2023 by the authors. |
| Subject Keyword | Moraceae Streblus taxoides antityrosine activity antibacterial activity melanin content intracellular tyrosinase activity |
| Content Type | Text |
| Resource Type | Article |
| Subject | Biochemistry Pharmacology, Toxicology and Pharmaceutics Microbiology Pharmacology (medical) Infectious Diseases Microbiology (medical) |
