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Immune Checkpoint Inhibitors: Changing the Treatment Landscape in Esophagogastric Adenocarcinoma.
| Content Provider | Europe PMC |
|---|---|
| Author | Lynch, Emer Duffy, Austin G. Kelly, Ronan J. |
| Editor | Nam, Seungyoon Lee, Jinhyuk |
| Copyright Year | 2023 |
| Abstract | In the West, recent decades have demonstrated an epidemiological trend towards esophago-gastric adenocarcinomas (EGAC), with considerable associated mortality. Historically, chemotherapy has represented the sole systemic treatment option in the advanced EGAC setting, in addition to complementing the role of surgery and radiotherapy in the case of localized disease. Immune checkpoint inhibitors (ICIs) represent a novel systemic therapeutic choice and have revolutionized the management of other malignancies, including melanoma and renal cell carcinomas. This article considers the rationale for ICIs in EGAC, reviews the evidence supporting their role in the current standard of care in EGAC, and briefly considers ongoing trials and future directions for the ICI class in EGAC. |
| Volume Number | 16 |
| PubMed Central reference number | PMC9865965 |
| Issue Number | 1 |
| PubMed reference number | 36678598 |
| Journal | Pharmaceuticals (Basel) |
| e-ISSN | 14248247 |
| DOI | 10.3390/ph16010102 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2023-01-10 |
| Access Restriction | Open |
| Rights License | Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). © 2023 by the authors. |
| Subject Keyword | Gastric cancer gastro-esophageal adenocarcinoma immune checkpoint inhibitor PD-L1 CTLA-4 |
| Content Type | Text |
| Resource Type | Article |
| Subject | Drug Discovery Pharmaceutical Science Molecular Medicine |
