NDLI: Role of Neoadjuvant Immune Checkpoint Inhibitors in Resectable Non-Small Cell Lung Cancer.

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Role of Neoadjuvant Immune Checkpoint Inhibitors in Resectable Non-Small Cell Lung Cancer.

Content Provider	Europe PMC
Author	Riano, Ivy Abuali, Inas Sharma, Aditya Durant, Jewelia Dragnev, Konstantin H.
Editor	Adashek, Jacob J
Copyright Year	2023
Abstract	The neoadjuvant use of immune checkpoint inhibitors (ICI) in resectable non-small cell lung cancer (NSCLC) is being increasingly adopted, but questions about the most appropriate applications remain. Although patients with resectable NSCLC are often treated with surgery and adjuvant chemotherapy or targeted therapies +/− radiotherapy, they still have a high risk of recurrence and death. In recent years, immune checkpoint inhibitors (ICI) (anti-PD-1/PD-L1 and anti-CTLA-4) have provided a new and effective therapeutic strategy for the treatment of advanced NSCLC. Therefore, it is possible that ICIs for early-stage NSCLC may follow the pattern established in metastatic disease. Currently, there are several ongoing trials to determine the efficacy in the neoadjuvant setting for patients with local or regional disease. To date, only nivolumab in combination with chemotherapy has been approved by the U.S. FDA in the preoperative setting, but data continue to evolve rapidly, and treatment guidelines need to be determined. In this article, we review the current preclinical and clinical evidence on neoadjuvant ICIs alone and combination in the treatment of early-stage NSCLC.
Volume Number	16
PubMed Central reference number	PMC9963056
Issue Number	2
PubMed reference number	37259381
Journal	Pharmaceuticals (Basel)
e-ISSN	14248247
DOI	10.3390/ph16020233
Language	English
Publisher	MDPI
Publisher Date	2023-02-03
Access Restriction	Open
Rights License	Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). © 2023 by the authors.
Subject Keyword	immune checkpoint inhibitors non-small cell lung cancer resectable lung cancer neoadjuvant treatment PD-L1 PD-1 CTL-4
Content Type	Text
Resource Type	Article
Subject	Drug Discovery Pharmaceutical Science Molecular Medicine

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