NDLI: Analysis of Therapeutic Decisions for Infantile Hemangiomas: A Prospective Study Comparing the Hemangioma Severity Scale with the Infantile Hemangioma Referral Score.

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Analysis of Therapeutic Decisions for Infantile Hemangiomas: A Prospective Study Comparing the Hemangioma Severity Scale with the Infantile Hemangioma Referral Score.

Content Provider	Europe PMC
Author	Qiu, Tong Yang, Kaiying Dai, Shiyi Chen, Siyuan Ji, Yi
Editor	Gefeller, Olaf
Copyright Year	2022
Abstract	Background: In view of the high incidence of infantile hemangioma (IH) in infants and young children, a comprehensive and reasonable evaluation scale for referral is urgently needed. This study compared the influence of the Hemangioma Severity Scale (HSS) and the Infantile Hemangioma Referral Score (IHReS) on treatment decisions for infantile hemangioma patients. Objective: We aimed to establish a reliable and effective evaluation method for referral. Methods: This was a prospective study to determine whether treatment was needed for IH patients after evaluation with the HSS and IHReS. Results: A total of 266 consecutive referred IH patients were evaluated for the risk of IH, and the treatment rate was 80.8%. The area under the curve (AUC) of the subject receiver operating characteristic curve (ROC) of treatment decision making after referral by the HSS was 0.703 (95% CI: 0.634–0.772), and after referral by the IHReS was 0.892 (95% CI: 0.824–0.960). Limitations: This was a single-center study. Conclusions: For decisions regarding the treatment of IH patients, the IHReS has a higher efficiency and sensitivity than the HSS. However, the specificity of the IHReS is lower than that of the HSS.
Volume Number	9
PubMed Central reference number	PMC9777170
Issue Number	12
PubMed reference number	36553295
Journal	Children (Basel)
e-ISSN	22279067
DOI	10.3390/children9121851
Language	English
Publisher	MDPI
Publisher Date	2022-11-28
Access Restriction	Open
Rights License	Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). © 2022 by the authors.
Subject Keyword	Hemangioma Severity Scale (HSS) Infantile Hemangioma Referral Score (IHReS) referral area under the curve (AUC) receiver operating characteristic curve (ROC) Fagan nomogram
Content Type	Text
Resource Type	Article
Subject	Pediatrics, Perinatology and Child Health

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Receiver operating characteristic curve (roc-auc).

Utility of the Infantile Hemangioma Referral Score (IHReS) as a decision-making tool for referral to treatment

Frequentist versus Bayesian approaches for AUC Confidence Interval Bounds

Frequentist versus Bayesian approaches for AUC Confidence Interval Bounds

Improving binary decisions

Exact Probability Distribution for the ROC Area under Curve.

Estimation of ROC curve with complex survey data

The Performance of a Risk Score in Predicting Undiagnosed Hyperglycemia

Comparing ROC curves derived from regression models

Analysis of Therapeutic Decisions for Infantile Hemangiomas: A Prospective Study Comparing the Hemangioma Severity Scale with the Infantile Hemangioma Referral Score.

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Analysis of Therapeutic Decisions for Infantile Hemangiomas: A Prospective Study Comparing the Hemangioma Severity Scale with the Infantile Hemangioma Referral Score.