Loading...
Please wait, while we are loading the content...
Similar Documents
Vitamin K2 (MK-7) Intercepts Keap-1/Nrf-2/HO-1 Pathway and Hinders Inflammatory/Apoptotic Signaling and Liver Aging in Naturally Aging Rat.
| Content Provider | Europe PMC |
|---|---|
| Author | El-Sherbiny, Mohamed Atef, Hoda Helal, Ghada M. Al-Serwi, Rasha Hamed Elkattawy, Hany A. Shaker, Gehan Ahmed Said, Eman Abulfaraj, Moaz Albalawi, Marzough A. Elsherbiny, Nehal M. |
| Editor | Moshage, Han |
| Copyright Year | 2022 |
| Abstract | Aging is a naturally occurring physiological process with a deleterious impact on various body organs and humans’ well-being. The aging population is increasing worldwide, which imposes the need for the exploration of nutritional options that can intercept the impact of the aging processed on various body organs. Vitamin K2 (VK2) is a fat-soluble vitamin with emerging evidence on its therapeutic merits. In the current study, natural aging induced a significant liver deterioration with a disrupted Keap-1/Nrf-2/HO-1 axis and increased COX-2, iNOS and TNF-α expression and apoptotic and fibrotic changes. VK2 administration, on the other hand, improved the biochemical indices of liver function (total protein, albumin, ALT and AST); the suppressed hepatic expression of Keap-1 and increased the hepatic expression of Nrf-2 with a parallel increase in the hepatic activity of HO-1. Subsequently, the liver content and hepatic expression of TNF-α, COX-2 and iNOS were significantly retracted. In context, the liver content and hepatic expression of the fibrotic biomarkers TGFβ and TIMP significantly retracted as well. Moreover, the TUNEL assay confirmed the retraction of liver apoptotic changes. Of notice, electron transmission microscope examination confirmed the preservation of mitochondrial functions and preservation of the ultra-microscopical structures. In conclusion, the VK2-mediated interception of aging-induced Keap-1/Nrf-2/HO-1 signaling suppressed the hepatic contents of inflammatory and fibrotic biomarkers, as well as apoptotic changes with preservation of the hepatic architectural and functional status. VK2 can be presumed to be an effective nutritional supplement to the aging population to spare the liver, amongst other body organs, against aging-induced deleterious injury. |
| Journal | Antioxidants (Basel, Switzerland) |
| Volume Number | 11 |
| PubMed Central reference number | PMC9687029 |
| Issue Number | 11 |
| PubMed reference number | 36358523 |
| e-ISSN | 20763921 |
| DOI | 10.3390/antiox11112150 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2022-10-30 |
| Access Restriction | Open |
| Rights License | Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). © 2022 by the authors. |
| Subject Keyword | aging vitamin K2 Nrf-2 COX-2 TIMP apoptosis |
| Content Type | Text |
| Resource Type | Article |
| Subject | Biochemistry Cell Biology Molecular Biology Physiology Clinical Biochemistry Food Science |
