Loading...
Please wait, while we are loading the content...
Obstructive Sleep Apnea is Associated with an Increased Prevalence of Polycythemia in Patients with Chronic Obstructive Pulmonary Disease.
| Content Provider | Europe PMC |
|---|---|
| Author | Zeng, Zhaofu Song, Yan He, Xin Yang, Haizhen Yue, Fang Xiong, Mengqing Hu, Ke |
| Copyright Year | 2022 |
| Abstract | PurposeChronic obstructive pulmonary disease (COPD) and obstructive sleep apnea (OSA) are associated with polycythemia. However, there still remain unanswered questions about the relationship between overlap syndrome (OVS), where OSA and COPD coexist, and polycythemia. Here, we aimed to establish the prevalence of polycythemia in OVS patients and to explore the impact of OSA on polycythemia.Patients and MethodsPatients with COPD underwent overnight polysomnography (PSG), pulmonary function tests, echocardiography, and complete blood counts. All patients were ethnic Han Chinese and free of prolonged oral corticosteroid use, hematological system disease, severe systemic disease, and other sleep-disordered breathing. OVS was defined as COPD patients with an apnea–hypopnea index ≥15 events/h, and polycythemia was defined as an Hb >165 g/L in men and >160 g/L in women.ResultsEight-hundred and eighty-six patients with COPD were included in the analysis. The prevalence of polycythemia was significantly higher in OVS patients than COPD-alone patients (6.4% vs 2.9%, p < 0.05). The prevalence of polycythemia increased with OSA severity (χ2 = 7.885, p = 0.007), but not in GOLD grade 3–4 COPD patients (χ2 = 0.190, p = 0.663). After adjusting for confounders, percentage of total sleep time with SaO2 <90% (TS90) remained independently associated with an increased odds of polycythemia (OR 1.030, 95% CI 1.015–1.046) and, with an increase in TS90, the hemoglobin increased, especially in GOLD grade 1–2 patients (p < 0.05).ConclusionPatients with OVS have a higher prevalence of polycythemia than those with COPD alone, and TS90 is an independent factor for polycythemia, especially in GOLD1-2 COPD patients. |
| Page Count | 10 |
| ISSN | 11769106 |
| Volume Number | 17 |
| PubMed Central reference number | PMC8769057 |
| PubMed reference number | 35068930 |
| Journal | International Journal of Chronic Obstructive Pulmonary Disease [Int J Chron Obstruct Pulmon Dis] |
| e-ISSN | 11782005 |
| DOI | 10.2147/COPD.S338824 |
| Language | English |
| Publisher | Dove |
| Publisher Date | 2022-01-15 |
| Access Restriction | Open |
| Rights License | This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). © 2022 Zeng et al. |
| Subject Keyword | chronic obstructive pulmonary disease obstructive sleep apnea overlap syndrome polycythemia |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pulmonary and Respiratory Medicine Public Health, Environmental and Occupational Health Health Policy |
