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Acute meningoencephalitis associated with SARS-CoV-2 infection in Colombia.
| Content Provider | Europe PMC |
|---|---|
| Author | Palacio-Toro, María A. Hernández-Botero, Johan S. Duque-Montoya, Daniela Osorio, Yuly Echeverry, Alejandro Osorio-Maldonado, Johanna J. Orjuela-Rodríguez, Marcela Rodríguez-Morales, Alfonso J. |
| Abstract | We present the case of a patient in the third decade of life, with asthma as comorbidity, who presented to the emergency department due to odynophagia, dyspnea, and cough of 2 days of evolution, later developing acute ventilatory failure requiring orotracheal intubation. The high-resolution chest tomography study showed consolidation due to a pneumonic process towards the posterior segment of the right lower lobe with areas of ground-glass infiltrates with a peripheral distribution. During the clinical course, the patient presented multiple seizure episodes that met the criteria for status epilepticus with MRI compatible with changes due to leptomeningitis. Given symptoms and thorax imaging, tests for SARS-CoV-2 ensued, with both positive RT-PCR in bronchoalveolar lavage and cerebrospinal fluid for the virus also positive. RT-PCR multiplex panel of meningitis/encephalitis results negative for 14 common organisms. A diagnosis of acute meningoencephalitis associated with COVID-19 was considered, with an adequate response to corticosteroid management; to our knowledge, this is the first adult patient with CNS involvement and CSF positive test in Latin America. |
| Related Links | https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC8569848&blobtype=pdf |
| ISSN | 13550284 |
| Journal | Journal of Neurovirology [J Neurovirol] |
| Volume Number | 27 |
| DOI | 10.1007/s13365-021-01023-6 |
| PubMed Central reference number | PMC8569848 |
| Issue Number | 6 |
| PubMed reference number | 34739714 |
| e-ISSN | 15382443 |
| Language | English |
| Publisher | Springer International Publishing |
| Publisher Date | 2021-11-05 |
| Publisher Place | Gewerbestrasse 11, Cham, Ch 6330, Switzerland |
| Access Restriction | Open |
| Rights License | This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. © Journal of NeuroVirology, Inc. 2021 |
| Subject Keyword | COVID-19 SARS-CoV-2 Encephalitis Seizures Colombia |
| Content Type | Text |
| Resource Type | Article |
| Subject | Neurology Virology Neurology (clinical) Cellular and Molecular Neuroscience |
