Meningoencephalitis associated with COVID-19: a systematic review.

Content Provider	Europe PMC
Author	Mondal, Ritwick Ganguly, Upasana Deb, Shramana Shome, Gourav Pramanik, Subhasish Bandyopadhyay, Deebya Lahiri, Durjoy
Abstract	With the growing number of COVID-19 cases in recent times. significant set of patients with extra pulmonary symptoms has been reported worldwide. Here we venture out to summarize the clinical profile, investigations, and radiological findings among patients with SARS-CoV-2-associated meningoencephalitis in the form of a systemic review. This review was carried out based on the existing PRISMA (Preferred Report for Systematic Review and Meta analyses) consensus statement. The data for this review was collected from four databases: Pubmed/Medline, NIH Litcovid, Embase, and Cochrane library and Preprint servers up till 30 June 2020. Search strategy comprised of a range of keywords from relevant medical subject headings which includes “SARS-COV-2,” “COVID-19,” and “meningoencephalitis.” All peer reviewed, case–control, case report, pre print articles satisfying our inclusion criteria were involved in the study. Quantitative data was expressed in mean ± SD, while the qualitative date in percentages. Paired t test was used for analysing the data based on differences between mean and respective values with a p < 0.05 considered to be statistically significant. A total of 61 cases were included from 25 studies after screening from databases and preprint servers, out of which 54 of them had completed investigation profile and were included in the final analysis. Clinical, laboratory findings, neuroimaging abnormalities, and EEG findings were analyzed in detail. This present review summarizes the available evidences related to the occurrence of meningoencephalitis in COVID-19.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC7765701&blobtype=pdf
ISSN	13550284
Journal	Journal of Neurovirology [J Neurovirol]
Volume Number	27
DOI	10.1007/s13365-020-00923-3
PubMed Central reference number	PMC7765701
Issue Number	1
PubMed reference number	33367960
e-ISSN	15382443
Language	English
Publisher	Springer International Publishing
Publisher Date	2020-12-26
Publisher Place	Gewerbestrasse 11, Cham, Ch 6330, Switzerland
Access Restriction	Open
Rights License	This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. © Journal of NeuroVirology, Inc. 2020
Subject Keyword	SARS-CoV-2 COVID-19 Coronavirus Clinical symptoms Neurological impairments Meningoencephalitis
Content Type	Text
Resource Type	Article
Subject	Neurology Virology Neurology (clinical) Cellular and Molecular Neuroscience