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Aflibercept Treatment Results and Association with Baseline Characteristics in Cases of Newly Diagnosed Neovascular Age-Related Macular Degeneration
| Content Provider | Europe PMC |
|---|---|
| Author | Kıyat, Pelin Menteş, Jale Nalçacı, Serhad Afrashi, Filiz Barış, Mine |
| Copyright Year | 2021 |
| Abstract | Objectives:To evaluate functional and anatomical responses to intravitreal aflibercept (IVA) treatment in newly diagnosed and untreated neovascular age-related macular degeneration (nvAMD) cases and to investigate the effect of baseline lesion characteristics on anatomical responses.Materials and Methods:This prospective, cross-sectional study included a series of 139 eyes of 133 patients that were diagnosed with active nvAMD and had not been treated. All eyes were subjected to complete ophthalmological examination, spectral-domain optical coherence tomography and fluorescein angiography, and 42 eyes also underwent indocyanine green angiography. IVA treatment was performed using a “treat and extend” regimen after 3 injections at 4-6 weeks intervals. Anatomical and functional responses at 4 weeks after the last injection were evaluated in eyes that completed 3 injections and the subgroup of eyes that completed 6 IVA injections. The effect of baseline lesion characteristics on IVA treatment results was also investigated.Results:All 139 eyes included in the study received 3 IVA injections (group 1) and 62 received 6 IVA injections. Both groups showed statistically significant improvement in best-corrected visual acuity (p<0.001 for both). The rate of complete response was 54.6% and 58.0% in groups 1 and 2, respectively. In group 1, the presence of pigment epithelial detachment (PED) and serous PED were identified as negative initial factors (p=0.043, p=0.005, respectively). However, none of the baseline characteristics were significantly associated with anatomical response in group 2.Conclusion:In our study, it was determined that successful anatomical and functional results were achieved with 3 and 6 doses of IVA in eyes with newly-diagnosed and untreated nvAMD. Among baseline characteristics, the presence of PED and serous PED in particular were found to be factors affecting treatment response negatively. |
| Related Links | https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC8251674&blobtype=pdf |
| ISSN | 21498695 |
| Journal | Turkish Journal of Ophthalmology [Turk J Ophthalmol] |
| Volume Number | 51 |
| DOI | 10.4274/tjo.galenos.2020.52460 |
| PubMed Central reference number | PMC8251674 |
| Issue Number | 3 |
| PubMed reference number | 34187151 |
| e-ISSN | 21498709 |
| Language | English |
| Publisher | Galenos Publishing |
| Publisher Date | 2021-06-01 |
| Access Restriction | Open |
| Rights License | This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. © Copyright 2021 by Turkish Ophthalmological Association | Turkish Journal of Ophthalmology, published by Galenos Publishing House. |
| Subject Keyword | Aflibercept anti-VEGF neovascular age-related macular degeneration |
| Content Type | Text |
| Resource Type | Article |
| Subject | Ophthalmology |
