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Refractory neovascular age-related macular degeneration: time-dependent changes of central retinal thickness with anti-VEGF treatment.
| Content Provider | Europe PMC |
|---|---|
| Author | Zola, Marta D’Alessandro, Elisa Sherif, Mohamed Nguyen, Audrey De Azevedo, Dominique Haeller, Céline Forestier, Edwige Mantel, Irmela |
| Abstract | PurposeTo assess the influence of time interval since last injection and time from baseline on central retinal thickness (CRT) in neovascular age-related macular degeneration (nAMD) with fluid refractory to monthly anti-VEGF treatment.MethodsThis retrospective study included nAMD eyes with incomplete response to anti-VEGF defined by the presence of intra- or subretinal fluid on optical coherence tomography despite maximal (monthly) anti-VEGF dosing. The outcome measure was CRT, and two time variables (time from last injection ant time from baseline) were the independent factors included in the individual correlation analyses. In addition, an association analysis was performed.ResultsSixty eyes of 56 patients (67.9% females, mean age: 78.7 ± 6.8 years) were included with a mean included time period of 35.6 months. A significant positive correlation between CRT and the time from last injection occurred in 24 (40%) and 25 (42%) eyes by univariate and multivariate analysis, respectively. Time from baseline was significantly correlated with CRT in 29 (48.3%) and 30 (50%) eyes by univariate and multivariate analysis, respectively. This correlation was positive in 12 (20%) and negative in 18 eyes (30%). No association with such correlation was found.ConclusionSo-called refractory nAMD frequently shows a correlation of CRT with the interval in days from the preceding anti-VEGF injection, revealing that there is a subgroup of short-term responsiveness of the residual fluid. Moreover, slower CRT changes may occur over the years, either decrease or increase. In case of a slow CRT increase, this might require a diagnostic workup and therapeutic change.Supplementary InformationThe online version contains supplementary material available at 10.1007/s00417-020-05000-3. |
| Related Links | https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC8166689&blobtype=pdf |
| ISSN | 0721832X |
| Journal | Graefe's Archive for Clinical and Experimental Ophthalmology [Graefes Arch Clin Exp Ophthalmol] |
| Volume Number | 259 |
| DOI | 10.1007/s00417-020-05000-3 |
| PubMed Central reference number | PMC8166689 |
| Issue Number | 6 |
| PubMed reference number | 33245426 |
| e-ISSN | 1435702X |
| Language | English |
| Publisher | Springer Berlin Heidelberg |
| Publisher Date | 2020-11-27 |
| Publisher Place | Berlin/Heidelberg |
| Access Restriction | Open |
| Rights License | Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. © The Author(s) 2020 |
| Subject Keyword | Aflibercept Anti-VEGF Central retinal thickness Neovascular age-related macular degeneration Optical coherence tomography Ranibizumab |
| Content Type | Text |
| Resource Type | Article |
| Subject | Ophthalmology Sensory Systems Cellular and Molecular Neuroscience |
