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Weight loss interventions in living donor liver transplantation as a tool in expanding the donor pool: A systematic review and meta-analysis.
| Content Provider | Europe PMC |
|---|---|
| Author | Trakroo, Sushrut Bhardwaj, Nakul Garg, Rajat Modaresi Esfeh, Jamak |
| Copyright Year | 2020 |
| Abstract | BACKGROUNDWith increasing rates of liver transplantation and a stagnant donor pool, the annual wait list removals have remained high. Living donor liver transplantation (LDLT) is an established modality in expanding the donor pool and is the primary method of liver donation in large parts of the world. Marginal living donors, including those with hepatic steatosis, have been used to expand the donor pool. However, due to negative effects of steatosis on graft and recipient outcomes, current practice excludes overweight or obese donors with more than 10% macro vesicular steatosis. This has limited a potentially important source to help expand the donor pool. Weight loss is known to improve or resolve steatosis and rapid weight loss with short-term interventions have been used to convert marginal donors to low-risk donors in a small series of studies. There is, however, a lack of a consensus driven standardized approach to such interventions. AIMTo assess the available data on using weight loss interventions in potential living liver donors with steatotic livers and investigated the feasibility, efficacy, and safety of using such donors on the donor, graft and recipient outcomes. The principal objective was to assess if using such treated donor livers, could help expand the donor pool.METHODSWe performed a comprehensive literature review and meta-analysis on studies examining the role of short-term weight loss interventions in potential living liver donors with hepatic steatosis with the aim of increasing liver donation rates and improving donor, graft, and recipient outcomes. RESULTSA total of 6 studies with 102 potential donors were included. Most subjects were males (71). All studies showed a significant reduction in body mass index post-intervention with a mean difference of -2.08 (-3.06, 1.10, I2 = 78%). A significant reduction or resolution of hepatic steatosis was seen in 93 of the 102 (91.2%). Comparison of pre- and post-intervention liver biopsies showed a significant reduction in steatosis with a mean difference of -21.22 (-27.02, -15.43, I2 = 56%). The liver donation rates post-intervention was 88.5 (74.5, 95.3, I2 = 42%). All donors who did not undergo LDLT had either recipient reasons or had fibrosis/steatohepatitis on post intervention biopsies. Post-operative biliary complications in the intervention group were not significantly different compared to controls with an odds ratio of 0.96 [(0.14, 6.69), I2 = 0]. The overall post-operative donor, graft, and recipient outcomes in treated donors were not significantly different compared to donors with no steatosis. CONCLUSIONUse of appropriate short term weight loss interventions in living liver donors is an effective tool in turning marginal donors to low-risk donors and therefore in expanding the donor pool. It is feasible and safe, with comparable donor, graft, and recipient outcomes, to non-obese donors. Larger future prospective studies are needed. |
| ISSN | 10079327 |
| Volume Number | 27 |
| PubMed Central reference number | PMC8240053 |
| Issue Number | 24 |
| PubMed reference number | 34239278 |
| Journal | World Journal of Gastroenterology [World J. Gastroenterol] |
| e-ISSN | 22192840 |
| DOI | 10.3748/wjg.v27.i24.3682 |
| Language | English |
| Publisher | Baishideng Publishing Group Inc |
| Publisher Date | 2021-06-01 |
| Access Restriction | Open |
| Rights License | This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Subject Keyword | Living donor liver transplant Living liver donors Liver steatosis Weight loss interventions Donor outcomes Recipient outcomes |
| Content Type | Text |
| Resource Type | Article |
| Subject | Gastroenterology |
