Efficacy and Safety of Weight Reduction of the Donor in Hepatic Steatosis for Living Donor Liver Transplantation.

Content Provider	Europe PMC
Author	Chung, Jae Hun Ryu, Je Ho Yang, Kwang Ho Choi, Byung Hyun Park, Youngmok Lee, Tae Beom Shim, Jae Ryong Ko, Hyo Jung Cho, Sung Hwan
Copyright Year	2020
Abstract	BackgroundUse of steatotic livers is a known risk factor for increased primary nonfunction after liver transplantation. This study investigated the efficacy and clinical outcome of simple weight reduction of steatosis for donors undergoing living-donor liver transplantation (LDLT).Material/MethodsWe defined two groups: the reduction group, which included donors with >30% macrovesicular steatosis and body mass index (BMI) >25 kg/m2, and the conventional group, which included donors with <30% macrovesicular steatosis. Donors in the reduction group were educated about the goal of voluntary weight reduction to lose 5% of body weight, not exceeding 1.6 kg/week, and attempted to maintain weight reduction for at least 8 weeks.ResultsWeight reduction significantly improved steatosis (40.71±14.56 vs. 7.867±2.67, p=0.000). Body weight and BMI were reduced in the weight reduction group (85.40±8.254 kg vs. 76.27±7.556 kg, p=0.052; and 28.89±2.303 kg/m2 vs. 26.16±1.629 kg/m2, p=0.025, respectively). The transplanted grafts of recipients and remnant livers of donors showed intact liver function, and there was no difference in liver function tests between the conventional and reduction groups. No significant difference in graft survival was observed.ConclusionsSimple weight reduction improves steatosis and contributes to safer LDLT for both recipient and donor. Importantly, according to our results, even steatotic livers can be used for LDLT after patients follow a simple weight reduction protocol.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC7393957&blobtype=pdf
ISSN	14259524
Journal	Annals of Transplantation [Ann Transplant]
Volume Number	25
PubMed Central reference number	PMC7393957
PubMed reference number	32690857
e-ISSN	23290358
DOI	10.12659/aot.923211
Language	English
Publisher	International Scientific Literature, Inc.
Publisher Date	2020-07-21
Access Restriction	Open
Rights License	This work is licensed under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) © Ann Transplant, 2020
Subject Keyword	Fatty Liver Liver Transplantation Living Donors Weight Loss
Content Type	Text
Resource Type	Article
Subject	Transplantation