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Short-term choroidal vascular changes after aflibercept therapy for neovascular age-related macular degeneration.
| Content Provider | Europe PMC |
|---|---|
| Author | Pellegrini, Marco Bernabei, Federico Mercanti, Andrea Sebastiani, Stefano Peiretti, Enrico Iovino, Claudio Casini, Giamberto Loiudice, Pasquale Scorcia, Vincenzo Giannaccare, Giuseppe |
| Abstract | IntroductionThe purpose of this study was to evaluate choroidal vascular changes in patients with neovascular age-related macular degeneration (nAMD) treated with aflibercept injection over a 3-month period.MethodsEnhanced depth imaging optical coherence tomography scans of 60 eyes with treatment-naïve nAMD and 60 unaffected fellow eyes were retrospectively analyzed. Data was collected at baseline and after 3 monthly intravitreal injections of aflibercept. The ImageJ software was used to binarize OCT scans and measure total choroid area (TCA), luminal area (LA), and stromal area (SA). Choroidal vascularity index (CVI) was defined as the ratio of LA to TCA.ResultsAfter treatment, subfoveal choroidal thickness (CT) in nAMD eyes significantly decreased from 210. 6 ± 61.6 to 194.6 ± 58.7 μm (P < 0.001), TCA from 1.620 ± 0.502 to 1.500 ± 0.451 mm2 (P < 0.001), LA from 1.075 ± 0.335 to 0.985 ± 0.307 mm2 (P < 0.001), SA from 0.545 ± 0.176 to 0.516 ± 0.153 mm2 (P = 0.005), and CVI from 66.36 ± 2.89 to 65.46 ± 2.87% (P = 0.009). The decrease of CVI after treatment was significantly correlated with baseline CVI (Rs = 0.466, P < 0.001), but not with the change in BCVA and presence of dry macula after treatment (always P > 0.05).ConclusionChoroidal thickness and vascularity significantly decreased after treatment with aflibercept in nAMD eyes. Besides the pharmacologic effect on the neovascular lesion, aflibercept may induce vascular changes also on the underlying choroid. |
| Related Links | https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC8016768&blobtype=pdf |
| ISSN | 0721832X |
| Journal | Graefe's Archive for Clinical and Experimental Ophthalmology [Graefes Arch Clin Exp Ophthalmol] |
| Volume Number | 259 |
| DOI | 10.1007/s00417-020-04957-5 |
| PubMed Central reference number | PMC8016768 |
| Issue Number | 4 |
| PubMed reference number | 33048236 |
| e-ISSN | 1435702X |
| Language | English |
| Publisher | Springer Berlin Heidelberg |
| Publisher Date | 2020-10-13 |
| Publisher Place | Berlin/Heidelberg |
| Access Restriction | Open |
| Rights License | Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. © The Author(s) 2020 |
| Subject Keyword | Age-related macular degeneration Anti-VEGF Choroidal vascularity index Optical coherence tomography |
| Content Type | Text |
| Resource Type | Article |
| Subject | Ophthalmology Sensory Systems Cellular and Molecular Neuroscience |
