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Adipose tissue and age‑dependent insulin resistance: New insights into WAT browning (Review).
| Content Provider | Europe PMC |
|---|---|
| Author | Wu, Chuanlong Yu, Pei Sun, Ruixin |
| Copyright Year | 2021 |
| Abstract | Insulin resistance (IR) is defined as impaired insulin function, reduced glucose uptake and increased glucose production, which can result in type II diabetes, metabolic syndrome and even bone metabolic disorders. A possible reason for the increasing incidence of IR is population aging. Adipose tissue (AT) is an important endocrine organ that serves a crucial role in whole-body energy homeostasis. AT can be divided into white AT (WAT), beige AT and brown AT (BAT). Several mechanisms have been previously associated with age-dependent IR in WAT. However, BAT, a metabolically active tissue, controls the levels of plasma glucose and triglyceride metabolism. Therefore, the present review aimed to summarize the mechanisms of age-dependent IR induced by AT and to determine the role of WAT browning in achieving positive therapeutic outcomes in age-dependent IR. |
| ISSN | 11073756 |
| Journal | International Journal of Molecular Medicine |
| Volume Number | 47 |
| PubMed Central reference number | PMC7952244 |
| Issue Number | 5 |
| PubMed reference number | 33693956 |
| e-ISSN | 1791244X |
| DOI | 10.3892/ijmm.2021.4904 |
| Language | English |
| Publisher | D.A. Spandidos |
| Publisher Date | 2021-03-11 |
| Access Restriction | Open |
| Rights License | This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. Copyright: © Wu et al. |
| Subject Keyword | insulin resistance aging white adipose tissue brown adipose tissue type II diabetes |
| Content Type | Text |
| Resource Type | Article |
| Subject | Genetics Medicine |
