Loading...
Please wait, while we are loading the content...
Similar Documents
The role of the programmed cell death protein-1/programmed death-ligand 1 pathway, regulatory T cells and T helper 17 cells in tumor immunity: a narrative review.
| Content Provider | Europe PMC |
|---|---|
| Author | Zhang, Lanfang Zhang, Mingjuan Xu, Jinxiu Li, Shan Chen, Yu Wang, Wenjing Yang, Juntian Li, Shengyun Gu, Meiling |
| Copyright Year | 2020 |
| Abstract | Tumor immunotherapy, especially that involving programmed cell death protein-1 (PD-1)/programmed death-ligand 1 (PD-L1) immunosuppressive checkpoint inhibitors, has become an important part of tumor treatment strategy in the past decade. Blocking PD-1/PD-L1 signaling pathway can reduce the inhibitory effect of PD-1 pathway on T cells, promote the anti-tumor activity of activated T cells, and prolong the remission period of tumor. While PD-1/PD-L1 immunotherapy is effective in the treatment of solid malignant tumors, it also has shortcomings, due to the complexity of the tumor microenvironment (TME). Regulatory T cells (Tregs) and T helper 17 (Th17) cells play an important role in the TME and are closely related to the occurrence and development of tumors. Tregs can inhibit the anti-tumor immune effect, while Th17 cells play a dual role in tumor immunity, which not only promotes tumorigenesis but also promotes anti-tumor immunity. In the occurrence and development of tumor, PD-1/PD-L1 pathway, Tregs and Th17 cells are interrelated. However, the complicated relationship between the PD-1/PD-L1 pathway, Tregs, and Th17 cells has not been fully clarified. Here, we summarize the immunoregulation mechanisms and discuss the crosstalk between the PD-1/PD-L1 pathway, Tregs, and Th17 cells, with the aim of providing novel insights for future cancer treatment. |
| ISSN | 23055839 |
| Volume Number | 8 |
| PubMed Central reference number | PMC7729304 |
| Issue Number | 22 |
| PubMed reference number | 33313271 |
| Journal | Annals of Translational Medicine [Ann Transl Med] |
| e-ISSN | 23055847 |
| DOI | 10.21037/atm-20-6719 |
| Language | English |
| Publisher | AME Publishing Company |
| Publisher Date | 2020-11-01 |
| Access Restriction | Open |
| Rights License | Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0. 2020 Annals of Translational Medicine. All rights reserved. |
| Subject Keyword | Tumor programmed cell death protein-1 (PD-1)/programmed death-ligand 1 (PD-L1) T helper 17 cells (Th17 cells) regulatory T cells (Tregs) |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine |
