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Diffusion tensor magnetic resonance imaging of white matter integrity in patients with HIV-associated neurocognitive disorders.
| Content Provider | Europe PMC |
|---|---|
| Author | Zhao, Tingting Chen, Jiehua Fang, Hang Fu, Danhui Su, Danke Zhang, Wei |
| Copyright Year | 2020 |
| Abstract | BackgroundThis study investigated the efficacy and neurotoxicity of highly active antiretroviral therapy (HAART) by evaluating white matter (WM) injury using diffusion tensor magnetic resonance imaging (DTI) in patients with human immunodeficiency virus (HIV)-associated neurocognitive disorders (HAND).MethodsForty-six patients with HAND underwent DTI before and every six months during HAART treatment. DTI data, including fractional anisotropy (FA) and mean diffusivity (MD) values of structural WM before and after HAART, were compared. The relationship between DTI values and plasma viral loads was tested. MD was more sensitive than FA for evaluating WM injury in HAND-positive patients.ResultsFollowing 12 months of HAART, increased MD values (compared to 6 months of HAART) were observed in the right temporal lobe, right parietal lobe, right occipital lobe, right anterior limb of the internal capsule, right lenticular nucleus, the right cerebral peduncle, left caudate nucleus, left dorsal thalamus, and left posterior limb of the internal capsule. MD values in the left genu of the internal capsule (r=0.350, P=0.017) and left corona radiata (r=0.338, P=0.021) were positively correlated with plasma viral loads.ConclusionsDTI may be useful for assessing the efficacy and neurotoxicity of HAART in HAND-positive patients. Starting HAART may halt WM injury; however, prolonged HAART could worsen WM injury, highlighting the importance of optimal HAART duration. |
| ISSN | 23055839 |
| Volume Number | 8 |
| PubMed Central reference number | PMC7661883 |
| Issue Number | 20 |
| PubMed reference number | 33209894 |
| Journal | Annals of Translational Medicine [Ann Transl Med] |
| e-ISSN | 23055847 |
| DOI | 10.21037/atm-20-6342 |
| Language | English |
| Publisher | AME Publishing Company |
| Publisher Date | 2020-10-01 |
| Access Restriction | Open |
| Rights License | Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0. 2020 Annals of Translational Medicine. All rights reserved. |
| Subject Keyword | Human immunodeficiency virus (HIV) white matter (WM) diffusion tensor imaging highly active antiretroviral therapy (HAART) |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine |
