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Combination antiretroviral therapy modulates the blood oxygen level–dependent amplitude in human immunodeficiency virus–seropositive patients
| Content Provider | Scilit |
|---|---|
| Author | Ances, Beau M. Roc, Anne C. Korczykowski, Marc Wolf, Ronald L. Kolson, Dennis L. |
| Copyright Year | 2008 |
| Description | Combination antiretroviral therapy (cART) limits human immunodeficiency virus (HIV) replication in the central nervous system (CNS) and prevents progressive neurological dysfunction. We examined if the degree of CNS penetration by cART, as estimated by the CNS penetration effectiveness (CPE) score, affects brain activity as measured by the amplitude of the blood oxygen level—dependent functional magnetic resonance imaging (BOLD fMRI) response. HIV+ patients on low-CPE cART (n =12) had a significantly greater BOLD fMRI response amplitude than HIV+ patients on high-CPE cART (n = 12) or seronegative controls (n =10). An increase in the BOLD fMRI response in HIV patients on low-CPE cART may reflect continued HIV replication in the CNS leading to increased oxidative stress and associated metabolic demands. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2819068/pdf https://link.springer.com/content/pdf/10.1080/13550280802298112.pdf |
| Ending Page | 424 |
| Page Count | 7 |
| Starting Page | 418 |
| ISSN | 13550284 |
| e-ISSN | 15382443 |
| DOI | 10.1080/13550280802298112 |
| Journal | Journal of NeuroVirology |
| Issue Number | 5 |
| Volume Number | 14 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2008-01-01 |
| Access Restriction | Open |
| Subject Keyword | Virology Combination Antiretroviral Therapy (cart) Functional Magnetic Resonance Imaging Hiv-associated Neurocognitive Disorders |
| Content Type | Text |
| Resource Type | Article |
| Subject | Neurology Virology Neurology (clinical) Cellular and Molecular Neuroscience |
