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An updated meta-analysis of 23 case-control studies on the association between miR-34b/c polymorphism and cancer risk.
| Content Provider | Europe PMC |
|---|---|
| Author | Li, Hua Diao, Shuling Li, Jingsen Ma, Baoxin Yuan, Shuanghu |
| Copyright Year | 2017 |
| Abstract | The association between in microRNA-34b/c gene rs4938723 polymorphisms and cancer risk remains inconclusive. This meta-analysis was performed to analyze the association between microRNA-34b/c rs4938723 polymorphism and risk for cancer development. In total, 304 studies from PubMed, Embase, Web of Science, Wanfang, and Chinese National Knowledge Infrastructure databases were examined, and 23 studies were included in this meta-analysis. The 23 selected studies involved 10,812 cancer cases and 11,719 controls. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to measure the strength of the association. Our results indicate a significant association between the rs4938723 polymorphism and cancer risk in the overdominant model (P heterogeneity = 0.018, OR = 1.093, and 95% CI = 1.015–1.177 for CT vs. CC/TT). Using a stratified subgroup analysis, rs4938723 polymorphisms were associated with an increased risk for hepatocellular carcinoma, but decreased risk for colorectal, gastric, and esophageal squamous cell cancer. These findings indicate that the rs4938723 gene is a susceptible locus for cancer. |
| Journal | Oncotarget |
| Volume Number | 8 |
| PubMed Central reference number | PMC5438700 |
| Issue Number | 17 |
| PubMed reference number | 28415817 |
| e-ISSN | 19492553 |
| DOI | 10.18632/oncotarget.16322 |
| Language | English |
| Publisher | Impact Journals LLC |
| Publisher Date | 2017-04-01 |
| Access Restriction | Open |
| Rights License | This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC-BY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Copyright: © 2017 Li et al. |
| Subject Keyword | rs4938723 polymorphism cancer risk systematic review meta-analysis |
| Content Type | Text |
| Resource Type | Article |
| Subject | Oncology |
