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Chemical Composition and Biological Activities of Methanolic Extract of Scrophularia Oxysepala Boiss.
| Content Provider | Europe PMC |
|---|---|
| Author | Pasdaran, Ardalan Delazar, Abbas Ayatollahi, Seyed Abdulmajid Pasdaran, Arsalan |
| Abstract | Isolated five known iridoids glycosides (Scrophuloside A, Harpagoside B, 5-hydroxyloganin, 8-O-acetylharpagide and 6-O-methyl,1-glucopyranosyl catalpol), one phenyl ethanoid glycoside (Verbascoside) and a phenyl ethanol amine (2-(4-Chlorobenzyl amino) ethanol) compound from the methanolic extract of aerial parts of Scrophularia oxysepala using by high performance liquid chromatographyare based on isocratic and liner gradients by C18 column. The structure elucidations of the isolated compounds were performed by spectroscopic methods including1H-NMR, 13C-NMR, 2 D NMR technique such as HMBC( in deuterated methanol as solvent), GC-MS and UV, also methanolic extract and fractions( fractionated on solid phase extraction on C18 cartridge(Spack-C18)) of this plant was tested for free radical scavenging properties toward the 1, 1-diphenyl-1-picrylhydrazyl (DPPH), general toxicity (Brine shrimp toxicity assay) , insecticidal ( Contact toxicity insecticidal assay) and antimalarial activities (hemebiocrystallization inhibition assay). |
| ISSN | 17350328 |
| Journal | Iranian Journal of Pharmaceutical Research : IJPR |
| Volume Number | 16 |
| PubMed Central reference number | PMC5423259 |
| Issue Number | 1 |
| PubMed reference number | 28496487 |
| e-ISSN | 17266890 |
| Language | English |
| Publisher | Shaheed Beheshti University of Medical Sciences |
| Publisher Date | 2017-01-01 |
| Publisher Place | Tehran, Iran |
| Access Restriction | Open |
| Rights License | This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Copyright © 2017 by School of Pharmacy, Shaheed Beheshti University of Medical Sciences and Health Services |
| Subject Keyword | Scrophulariaoxysepala phenyl ethanol amine Iridoids glycosides radical scavenging general toxicity antimalarial activity insecticidal activity |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pharmacology, Toxicology and Pharmaceutics Pharmacology (medical) |
