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Anti-Adipogenic Effects of Ethanol Extracts Prepared from Selected Medicinal Herbs in 3T3-L1 Cells.
| Content Provider | Europe PMC |
|---|---|
| Author | Park, Min-Jun Song, Ji-Hye Shon, Myung-Soo Kim, Hae Ok Kwon, O Jun Roh, Seong-Soo Kim, Choon Young Kim, Gyo-Nam |
| Copyright Year | 2016 |
| Abstract | Obesity is a major risk factor for various metabolic diseases such as cardiovascular disease, hypertension, and type 2 diabetes mellitus. In this study, we prepared ethanol extracts from Agastache rugosa (ARE), Chrysanthemum zawadskii (CZE), Mentha arvensis (MAE), Perilla frutescens (PFE), Leonurus sibiricus (LSE), Gardenia jasminoides (GJE), and Lycopus coreanus (LCE). The anti-oxidant and anti-adipogenic effects were evaluated. The IC50 values for ascorbic acid and LCE against 2,2-diphenyl-1-picrylhydrazyl radicals were 246.2 μg/mL and 166.2 μg/mL, respectively, followed by ARE (186.6 μg/mL), CZE (198.6 μg/mL), MAE (337.1 μg/mL), PFE (415.3 μg/mL), LSE (548.2 μg/mL), and GJE (626.3 μg/mL). In non-toxic concentration ranges, CZE had a strong inhibitory effect against 3T3-L1 adipogenes (84.5%) than those of the other extracts. Furthermore, the anti-adipogenic effect of CZE is largely limited in the early stage of adipogenesis, and we revealed that the inhibitory role of CZE in adipogenesis is required for the activation of Wnt signaling. Our results provide scientific evidence that the anti-adipogenic effect of CZE can be applied as an ingredient for the development of functional foods and nutri-cosmetics for obesity prevention. |
| Related Links | https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC5063208&blobtype=pdf |
| ISSN | 22871098 |
| Journal | Preventive Nutrition and Food Science [Prev Nutr Food Sci] |
| Volume Number | 21 |
| DOI | 10.3746/pnf.2016.21.3.227 |
| PubMed Central reference number | PMC5063208 |
| Issue Number | 3 |
| PubMed reference number | 27752499 |
| e-ISSN | 22878602 |
| Language | English |
| Publisher | The Korean Society of Food Science and Nutrition |
| Publisher Date | 2016-09-30 |
| Access Restriction | Open |
| Rights License | This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Copyright © 2016 by The Korean Society of Food Science and Nutrition |
| Subject Keyword | Chrysanthemum zawadskii adipognesis obesity Wnt signaling medicinal herb |
| Content Type | Text |
| Resource Type | Article |
| Subject | Nutrition and Dietetics Food Science |
