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Association of glutathione S-transferase T1 and M1 polymorphisms with prostate cancer susceptibility in populations of Asian descent: a meta-analysis.
| Content Provider | Europe PMC |
|---|---|
| Author | Cao, Da-Long Ye, Ding-Wei Dai, Bo Zhang, Hai-Liang Shen, Yi-Jun Zhu, Yao Zhu, Yi-Ping Shi, Guo-Hai Ma, Chun-Guang Xiao, Wen-Jun Qin, Xiao-Jian Lin, Guo-Wen |
| Copyright Year | 2015 |
| Abstract | BackgroundGenetic polymorphism was hypothesized to be reason of variation in prostate cancer incidence among different racial group. Based on that published data on the association of prostate cancer susceptibility with polymorphisms in genes encoding Glutathione S-transferases (GSTs) were inconclusive, the aim of this study was to more precisely address the role of GSTs polymorphisms (especially, GSTT1 and GSTM1 deletions) on prostate cancer risk in Asian descent.MethodsA meta-analysis including 8 articles with 711 cases and 1122 controls for GSTT1 and 1098 cases and 1588 controls for GSTM1 was performed.ResultsSignificantly increased prostate cancer risk was found among subjects carrying GSTM1 null genotype (odds ratio (OR) = 1.403; 95% confidence interval (CI) = 1.088 – 1.808) but not among subjects carrying GSTT1 deletion genotype (OR = 0.959; 95%CI = 0.709 – 1.297). When stratified by country, the null genotype of GSTT1 neither increased nor decreased prostate cancer risk significantly in China (OR = 1.355; 95%CI = 0.895 – 2.049), Japan (OR = 0.812; 95%CI = 0.545 – 1.211), and Korea (OR = 1.056; 95%CI = 0.727 – 1.534). While significant association of elevated prostate cancer risk with GSTM1 deletion were found in China (OR = 1.665; 95%CI = 1.324 – .094) and Korea (OR = 1.914; 95%CI = 1.311 – 2.793) but not in Japan (OR = 0.980; 95%CI = 0.726 – 1.321).ConclusionIn summary, this meta-analysis suggested that the null genotype of GSTM1 rather than GSTT1 may be involved in the etiology of prostate cancer in Asian population. |
| Journal | Oncotarget |
| Volume Number | 6 |
| PubMed Central reference number | PMC4742145 |
| Issue Number | 34 |
| PubMed reference number | 26416453 |
| e-ISSN | 19492553 |
| DOI | 10.18632/oncotarget.5346 |
| Language | English |
| Publisher | Impact Journals LLC |
| Publisher Date | 2015-11-01 |
| Access Restriction | Open |
| Rights License | This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Copyright: © 2015 Cao et al. |
| Subject Keyword | prostate cancer susceptibility polymorphism glutathione S-transferases T1 glutathione S-transferases M1 |
| Content Type | Text |
| Resource Type | Article |
| Subject | Oncology |
