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Heart-type fatty acid binding protein and high-sensitivity troponin T are myocardial damage markers that could predict adverse clinical outcomes in patients with peripheral artery disease.
| Content Provider | Europe PMC |
|---|---|
| Author | Otaki, Yoichiro Takahashi, Hiroki Watanabe, Tetsu Yamaura, Gensai Funayama, Akira Arimoto, Takanori Shishido, Tetsuro Miyamoto, Takuya Kubota, Isao |
| Copyright Year | 2015 |
| Abstract | BackgroundDespite many recent advances in endovascular therapy (EVT), peripheral artery disease (PAD) is an increasing health problem with high mortality. Heart-type fatty acid-binding protein (H-FABP) and high-sensitivity troponin T (hsTnT) are markers of ongoing myocardial damage and have been reported to be useful indicators of future cardiovascular events. However, it remains to be determined whether H-FABP and hsTnT can predict adverse clinical outcomes in patients with PAD.Methods and resultsWe enrolled 208 de novo PAD patients who underwent EVT. Serum H-FABP and hsTnT were measured in all patients before EVT. During the median follow-up period of 694 days, there were 40 major adverse cardiovascular and cerebrovascular events (MACCEs) including all-cause deaths, and re-hospitalizations due to cardiovascular and cerebrovascular diseases and amputations. H-FABP and hsTnT were found to be higher in patients with critical limb ischemia (CLI) compared to those without this condition. Multivariate Cox proportional hazard regression analysis revealed that both H-FABP and hsTnT were independent predictors of MACCEs after adjustment for confounding factors. Kaplan–Meier analysis demonstrated that patients in the highest tertile according to H-FABP levels, as well as those in the highest hsTnT tertile, were at greatest risk for MACCEs. The net reclassification index was significantly improved by the addition of H-FABP as well as the addition of hsTnT to traditional risk factors.ConclusionThe myocardial damage markers H-FABP and hsTnT were increased in PAD patients with CLI and could predict MACCEs in PAD patients. |
| Related Links | https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC4661598&blobtype=pdf |
| Journal | BBA Clinical [BBA Clin] |
| Volume Number | 4 |
| DOI | 10.1016/j.bbacli.2015.06.003 |
| PubMed Central reference number | PMC4661598 |
| PubMed reference number | 26673681 |
| e-ISSN | 22146474 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2015-06-18 |
| Access Restriction | Open |
| Rights License | This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). © 2015 The Authors |
| Subject Keyword | Heart-type fatty acid binding protein High-sensitivity troponin T Peripheral artery disease Major adverse cardiovascular and cerebrovascular events |
| Content Type | Text |
| Resource Type | Article |
| Subject | Physiology (medical) Molecular Medicine Pathology and Forensic Medicine |
