NDLI: Heart fatty acid binding protein and cardiac troponin T plasma concentrations as markers for myocardial infarction after coronary artery ligation in mice

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Heart fatty acid binding protein and cardiac troponin T plasma concentrations as markers for myocardial infarction after coronary artery ligation in mice

Content Provider	Semantic Scholar
Author	Aartsen, Wendy M. Pelsers, M. M. A. L. Hermens, Wim Th. Glatz, J. F. C. Daemen, M. J. A. P. Smits, J. F. M.
Copyright Year	2000
Abstract	Abstract. Ligation of the main left coronary artery in mice serves as a model for myocardial infarction (MI). We tested whether plasma concentrations of heart-type fatty acid-binding protein (H-FABP) and/or cardiac troponin T (cTnT) discriminate between infarcted and sham-operated mice and allow estimation of infarct size. Mice were subjected to coronary artery ligation or sham surgery and release curves of H-FABP and cTnT were determined. At 4 h after surgery the mean (±SD) H-FABP plasma concentration was 461±134 µg/l (n=10) in MI and 185±51 µg/l (n=6; P<0.001) in sham-operated mice. By 24 h after surgery H-FABP levels had returned to normal in both groups. cTnT plasma concentrations increased up to 48 h after MI to 13.5±6.2 µg/l (n=6; P<0.001) compared with 0.031±0.063 µg/l (n=7) in sham-operated mice. Linear regression analysis revealed a significant correlation between plasma H-FABP at 4 h and infarct size assessed 7 days after surgery. Plasma cTnT did not correlate significantly with infarct size. In conclusion, plasma cTnT concentration at 48 h after infarction can be used to distinguish MI from sham mice, whereas H-FABP concentration at 4 h can be used for stratification of animals according to infarct size.
Starting Page	416
Ending Page	422
Page Count	7
File Format	PDF HTM / HTML
DOI	10.1007/s004249900180
PubMed reference number	10678737
Journal	Medline
Volume Number	439
Alternate Webpage(s)	https://page-one.springer.com/pdf/preview/10.1007/s004249900180
Alternate Webpage(s)	https://doi.org/10.1007/s004249900180
Journal	Pflügers Archiv
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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