Loading...
Please wait, while we are loading the content...
Similar Documents
Atherosclerosis: a chronic inflammatory disease mediated by mast cells.
| Content Provider | Europe PMC |
|---|---|
| Author | Conti, Pio Shaik-Dasthagirisaeb, Yazdami |
| Copyright Year | 2015 |
| Abstract | Inflammation is a process that plays an important role in the initiation and progression of atherosclerosis and immune disease, involving multiple cell types, including macrophages, T-lymphocytes, endothelial cells, smooth muscle cells and mast cells. The fundamental damage of atherosclerosis is the atheromatous or fibro-fatty plaque which is a lesion that causes several diseases. In atherosclerosis the innate immune response, which involves macrophages, is initiated by the arterial endothelial cells which respond to modified lipoproteins and lead to Th1 cell subset activation and generation of inflammatory cytokines and chemoattractant chemokines. Other immune cells, such as CD4+ T inflammatory cells, which play a critical role in the development and progression of atherosclerosis, and regulatory T cells [Treg], which have a protective effect on the development of atherosclerosis are involved. Considerable evidence indicates that mast cells and their products play a key role in inflammation and atherosclerosis. Activated mast cells can have detrimental effects, provoking matrix degradation, apoptosis, and enhancement as well as recruitment of inflammatory cells, which actively contributes to atherosclerosis and plaque formation. Here we discuss the relationship between atherosclerosis, inflammation and mast cells. |
| Related Links | https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC4655391&blobtype=pdf |
| ISSN | 14263912 |
| Journal | Central-European Journal of Immunology [Cent Eur J Immunol] |
| Volume Number | 40 |
| DOI | 10.5114/ceji.2015.54603 |
| PubMed Central reference number | PMC4655391 |
| Issue Number | 3 |
| PubMed reference number | 26648785 |
| e-ISSN | 16444124 |
| Language | English |
| Publisher | Polish Society of Experimental and Clinical Immunology |
| Publisher Date | 2015-10-15 |
| Access Restriction | Open |
| Rights License | This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial 3.0 Unported License, permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Copyright © Central European Journal of Immunology 2015 |
| Subject Keyword | leukocytes inflammation mast cells athersclerosis |
| Content Type | Text |
| Resource Type | Article |
| Subject | Immunology and Allergy Immunology |
