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Influence of toxicologically relevant metals on human epigenetic regulation.
| Content Provider | Europe PMC |
|---|---|
| Author | Ryu, Hyun-Wook Lee, Dong Hoon Won, Hye-Rim Kim, Kyeong Hwan Seong, Yun Jeong Kwon, So Hee |
| Copyright Year | 2015 |
| Abstract | Environmental toxicants such as toxic metals can alter epigenetic regulatory features such as DNA methylation, histone modification, and non-coding RNA expression. Heavy metals influence gene expression by epigenetic mechanisms and by directly binding to various metal response elements in the target gene promoters. Given the role of epigenetic alterations in regulating genes, there is potential for the integration of toxic metal-induced epigenetic alterations as informative factors in the risk assessment process. Here, we focus on recent advances in understanding epigenetic changes, gene expression, and biological effects induced by toxic metals. |
| Related Links | https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC4395649&blobtype=pdf |
| ISSN | 19768257 |
| Journal | Toxicological Research [Toxicol Res] |
| Volume Number | 31 |
| PubMed Central reference number | PMC4395649 |
| Issue Number | 1 |
| PubMed reference number | 25874027 |
| e-ISSN | 22342753 |
| DOI | 10.5487/tr.2015.31.1.001 |
| Language | English |
| Publisher | The Korean Society Of Toxicology |
| Publisher Date | 2015-03-01 |
| Access Restriction | Open |
| Rights License | This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Copyright © 2015, The Korean Society Of Toxicology |
| Subject Keyword | Epigenetics Gene expression DNA methylation Histone modification Noncoding RNA Heavy metal Environmental exposure |
| Content Type | Text |
| Resource Type | Article |
| Subject | Health, Toxicology and Mutagenesis Toxicology |
