NDLI: Influence of Toxicologically Relevant Metals on Human Epigenetic Regulation

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Influence of Toxicologically Relevant Metals on Human Epigenetic Regulation

Content Provider	Semantic Scholar
Author	Ryu, Hyun-Wook Lee, Dong Hoon Won, Hye-Rim Kim, Kyeong Hwan Seong, Yun Jeong Kwon, So Hee
Copyright Year	2015
Abstract	Environmental toxicants such as toxic metals can alter epigenetic regulatory features such as DNA methylation, histone modification, and non-coding RNA expression. Heavy metals influence gene expression by epigenetic mechanisms and by directly binding to various metal response elements in the target gene promoters. Given the role of epigenetic alterations in regulating genes, there is potential for the integration of toxic metal-induced epigenetic alterations as informative factors in the risk assessment process. Here, we focus on recent advances in understanding epigenetic changes, gene expression, and biological effects induced by toxic metals.
Starting Page	1
Ending Page	9
Page Count	9
File Format	PDF HTM / HTML
DOI	10.5487/TR.2015.31.1.001
PubMed reference number	25874027
Journal	Medline
Volume Number	31
Alternate Webpage(s)	https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/62/80/toxicr-31-1.PMC4395649.pdf
Alternate Webpage(s)	http://ocean.kisti.re.kr/downfile/volume/ksot/DSHHBQ/2015/v31n1/DSHHBQ_2015_v31n1_1.pdf
Alternate Webpage(s)	https://doi.org/10.5487/TR.2015.31.1.001
Journal	Toxicological research
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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