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Bamboo salt attenuates CCl4-induced hepatic damage in Sprague-Dawley rats.
| Content Provider | Europe PMC |
|---|---|
| Author | Zhao, Xin Song, Jia-Le Kil, Jeung-Ha Park, Kun-Young |
| Copyright Year | 2013 |
| Abstract | Bamboo salt, a Korean folk medicine, is prepared with solar salt (sea salt) and baked several times at high temperatures in a bamboo case. In this study, we compared the preventive effects of bamboo salt and purified and solar salts on hepatic damage induced by carbon tetrachloride in Sprague-Dawley rats. Compared with purified and solar salts, bamboo salts prevented hepatic damage in rats, as evidenced by significantly reduced serum levels of aspartate aminotransferase, alanine aminotransferase, and lactate dehydrogenase (P < 0.05). Bamboo salt (baked 9×) triggered the greatest reduction in these enzyme levels. In addition, it also reduced the levels of the proinflammatory cytokines interleukin (IL)-6, interferon (IFN)-γ, and tumor necrosis factor (TNF)-α. Histopathological sections of liver tissue demonstrated the protective effect of bamboo salt, whereas sections from animals treated with the other salt groups showed a greater degree of necrosis. We also performed reverse transcription-polymerase chain reaction and western blot analyses of the inflammation-related genes iNOS, COX-2, TNF-α, and IL-1β in rat liver tissues. Bamboo salt induced a significant decrease (~80%) in mRNA and protein expression levels of COX-2, iNOS, TNF-α, and IL-1β, compared with the other salts. Thus, we found that baked bamboo salt preparations could prevent CCl4-induced hepatic damage in vivo. |
| ISSN | 19761457 |
| Journal | Nutrition Research and Practice |
| Volume Number | 7 |
| PubMed Central reference number | PMC3746161 |
| Issue Number | 4 |
| PubMed reference number | 23964314 |
| e-ISSN | 20056168 |
| DOI | 10.4162/nrp.2013.7.4.273 |
| Language | English |
| Publisher | The Korean Nutrition Society and the Korean Society of Community Nutrition |
| Publisher Date | 2013-08-07 |
| Access Restriction | Open |
| Rights License | This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. ©2013 The Korean Nutrition Society and the Korean Society of Community Nutrition |
| Subject Keyword | Bamboo salt hepatic damage CCl4 cytokines inflammation |
| Content Type | Text |
| Resource Type | Article |
| Subject | Nutrition and Dietetics Food Science |
