NDLI: The flexible gene pool of Propionibacterium acnes.

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The flexible gene pool of Propionibacterium acnes.

Content Provider	Europe PMC
Author	Brüggemann, Holger Lomholt, Hans B. Kilian, Mogens
Copyright Year	2012
Abstract	Propionibacterium acnes is a Gram-positive bacterium that is intimately associated with humans. The nature and consequences of this symbiosis are poorly understood; it might comprise both mutualistic and parasitic properties. Recent advances in distinguishing phylotypes of P. acnes have revealed that certain type I lineages are predominantly associated with acne vulgaris. Genome analyses revealed a highly conserved core genome and the existence of island-like genomic regions and possible mobile genetic elements as part of the flexible gene pool. The analysis of clustered regularly interspaced short palindromic repeats (CRISPR), found exclusively in type II P. acnes, recently revealed the presence of CRISPR spacers that derived from mobile genetic elements. These elements are present in a subset of P. acnes type I lineages. Their significance for type-specific host-interacting properties and their contribution to pathogenicity is currently under investigation.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC3463471&blobtype=pdf
ISSN	21592543
Volume Number	2
DOI	10.4161/mge.21204
PubMed Central reference number	PMC3463471
Issue Number	3
PubMed reference number	23061021
Journal	Mobile Genetic Elements [Mob Genet Elements]
e-ISSN	2159256X
Language	English
Publisher	Landes Bioscience
Publisher Date	2012-05-01
Access Restriction	Open
Rights License	This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited. Copyright © 2012 Landes Bioscience
Subject Keyword	Propionibacterium acnes acne vulgaris clustered regularly interspaced short palindromic repeats (CRISPR) mobile genetic element multilocus sequence typing tight adherence
Content Type	Text
Resource Type	Article
Subject	Genetics Biochemistry

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