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The estrogenic effect of bisphenol A disrupts pancreatic beta-cell function in vivo and induces insulin resistance.
| Content Provider | Europe PMC |
|---|---|
| Author | Alonso-Magdalena, Paloma Morimoto, Sumiko Ripoll, Cristina Fuentes, Esther Nadal, Angel |
| Copyright Year | 2006 |
| Abstract | The function of the pancreatic β-cell is the storage and release of insulin, the main hormone involved in blood glucose homeostasis. The results in this article show that the widespread environmental contaminant bisphenol-A (BPA) imitates 17β-estradiol (E2) effects in vivo on blood glucose homeostasis through genomic and nongenomic pathways. The exposure of adult mice to a single low dose (10 μg/kg) of either E2 or BPA induces a rapid decrease in glycemia that correlates with a rise of plasma insulin. Longer exposures to E2 and BPA induce an increase in pancreatic β-cell insulin content in an estrogen-receptor–dependent manner. This effect is visible after 2 days of treatment and starting at doses as low as 10 μg/kg/day. After 4 days of treatment with either E2 or BPA, these mice developed chronic hyperinsulinemia, and their glucose and insulin tolerance tests were altered. These experiments unveil the link between environmental estrogens and insulin resistance. Therefore, either abnormal levels of endogenous estrogens or environmental estrogen exposure enhances the risk of developing type 2 diabetes mellitus, hypertension, and dyslipidemia. |
| ISSN | 00916765 |
| Journal | Environmental Health Perspectives |
| Volume Number | 114 |
| PubMed Central reference number | PMC1332664 |
| Issue Number | 1 |
| PubMed reference number | 16393666 |
| e-ISSN | 15529924 |
| DOI | 10.1289/ehp.8451 |
| Language | English |
| Publisher | National Institute of Environmental Health Sciences |
| Publisher Date | 2006-01-01 |
| Access Restriction | Open |
| Rights License | Publication of EHP lies in the public domain and is therefore without copyright. All text from EHP may be reprinted freely. Use of materials published in EHP should be acknowledged (for example, ?Reproduced with permission from Environmental Health Perspectives?); pertinent reference information should be provided for the article from which the material was reproduced. Articles from EHP, especially the News section, may contain photographs or illustrations copyrighted by other commercial organizations or individuals that may not be used without obtaining prior approval from the holder of the copyright. |
| Subject Keyword | bisphenol A diabetes endocrine disruptors estradiol estrogen receptor insulin islet of Langerhans nongenomic xenoestrogens |
| Content Type | Text |
| Resource Type | Article |
| Subject | Health, Toxicology and Mutagenesis Public Health, Environmental and Occupational Health |
