Research The Estrogenic Effect of Bisphenol A Disrupts Pancreatic β-Cell Function In Vivo and Induces Insulin Resistance

Content Provider	CiteSeerX
Author	Fuentes, Esther Morimoto, Sumiko Nadal, Angel Ripoll, Cristina Elche, Hernández Alonso-Magdalena, Paloma
Abstract	The function of the pancreatic β-cell is the storage and release of insulin, the main hormone involved in blood glucose homeostasis. The results in this article show that the widespread environmental contaminant bisphenol-A (BPA) imitates 17β-estradiol (E 2) effects in vivo on blood glucose homeostasis through genomic and nongenomic pathways. The exposure of adult mice to a single low dose (10 µg/kg) of either E 2 or BPA induces a rapid decrease in glycemia that correlates with a rise of plasma insulin. Longer exposures to E 2 and BPA induce an increase in pancreatic β-cell insulin content in an estrogen-receptor–dependent manner. This effect is visible after 2 days of treatment and starting at doses as low as 10 µg/kg/day. After 4 days of treatment with either E 2 or BPA, these mice developed chronic hyperinsulinemia, and their glucose and insulin tolerance tests were altered. These experiments unveil the link between environmental estrogens and insulin resistance. Therefore, either abnormal levels of endogenous estrogens or environmental estrogen exposure enhances the risk of developing type 2 diabetes mellitus, hypertension, and dyslipidemia. Key words: bisphenol A, diabetes, endocrine disruptors, estradiol, estrogen receptor, insulin, islet of Langerhans, nongenomic, xenoestrogens. Environ Health Perspect 114:106–112 (2006). doi:10.1289/ehp.8451 available via
File Format	PDF
Access Restriction	Open
Subject Keyword	Estrogenic Effect Estrogen Receptor Endocrine Disruptors Endogenous Estrogen Abnormal Level Widespread Environmental Contaminant Bisphenol-a Chronic Hyperinsulinemia Adult Mouse Estrogen-receptor Dependent Manner Main Hormone Pancreatic Cell Insulin Content Bisphenol Disrupts Pancreatic Cell Function Article Show Single Low Dose Insulin Resistance Blood Glucose Homeostasis Insulin Tolerance Test Environmental Estrogen Exposure Induces Insulin Resistance Plasma Insulin Nongenomic Pathway Kg Day Environmental Estrogen Environ Health Perspect Rapid Decrease Pancreatic Cell
Content Type	Text
Resource Type	Article