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Modified Sulfanilamide Release from Intelligent Poly(N-isopropylacrylamide) Hydrogels.
| Content Provider | Europe PMC |
|---|---|
| Author | Dinić, Ana Nikolić, Vesna Nikolić, Ljubiša Ilić-Stojanović, Snežana Najman, Stevo Urošević, Maja Gajić, Ivana |
| Editor | Bonacucina, Giulia |
| Copyright Year | 2023 |
| Abstract | The aim of this study was to examine homopolymeric poly(N-isopropylacrylamide), p(NIPAM), hydrogels cross-linked with ethylene glycol dimethacrylate as carriers for sulfanilamide. Using FTIR, XRD and SEM methods, structural characterization of synthesized hydrogels before and after sulfanilamide incorporation was performed. The residual reactants content was analyzed using the HPLC method. The swelling behavior of p(NIPAM) hydrogels of different crosslinking degrees was monitored in relation to the temperature and pH values of the surrounding medium. The effect of temperature, pH, and crosslinker content on the sulfanilamide release from hydrogels was also examined. The results of the FTIR, XRD, and SEM analysis showed that sulfanilamide is incorporated into the p(NIPAM) hydrogels. The swelling of p(NIPAM) hydrogels depended on the temperature and crosslinker content while pH had no significant effect. The sulfanilamide loading efficiency increased with increasing hydrogel crosslinking degree, ranging from 87.36% to 95.29%. The sulfanilamide release from hydrogels was consistent with the swelling results—the increase of crosslinker content reduced the amount of released sulfanilamide. After 24 h, 73.3–93.5% of incorporated sulfanilamide was released from the hydrogels. Considering the thermosensitivity of hydrogels, volume phase transition temperature close to the physiological temperature, and the satisfactory results achieved for sulfanilamide incorporation and release, it can be concluded that p(NIPAM) based hydrogels are promising carriers for sulfanilamide. |
| Journal | Pharmaceutics |
| Volume Number | 15 |
| PubMed Central reference number | PMC10304515 |
| Issue Number | 6 |
| PubMed reference number | 37376197 |
| e-ISSN | 19994923 |
| DOI | 10.3390/pharmaceutics15061749 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2023-06-16 |
| Access Restriction | Open |
| Rights License | Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). © 2023 by the authors. |
| Subject Keyword | sulfanilamide N-isopropylacrylamide thermosensitive hydrogels swelling kinetics characterization release kinetics |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pharmaceutical Science |
