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Anticancer drug release from poly ( N-isopropylacrylamide / itaconic acid ) copolymeric hydrogels
| Content Provider | Semantic Scholar |
|---|---|
| Author | Taş, Bahar Delena Kayaman-Apohanb, N. Güvenc, O. Baysald, B. M. |
| Copyright Year | 2005 |
| Abstract | The drug uptake and release of anticancer drug from N-isopropylacrylamide/itaconic acid copolymeric hydrogels containing 0–3mol% of itaconic acid irradiated at 48 kGy have been investigated. 5-Fluorouracil (5-FU) is used as a model anticancer drug. The effect of 5-FU solution on swelling characteristics of PNIPAAm and P(NIPAAm/IA) copolymeric hydrogels have also been studied. The percent swelling, equilibrium swelling, equilibrium water/5-FU content and diffusion constant values are evaluated for poly(N-isopropylacrylamide) (PNIPAAm) and poly(Nisopropylacrylamide/itaconic) (P(NIPAAm/IA)) hydrogels at 130 ppm of 5-FU solution at room temperature. Diffusion of 5-FU solution into the hydrogels has been found to be the non-Fickian type. Finally, the kinetics of drug release from the hydrogels are examined. r 2004 Elsevier Ltd. All rights reserved. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.polymer.hacettepe.edu.tr/pdf/Anticancer%20drug%20release%20from%20polyN-isopropylacrylamide.pdf |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |