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Transient Decrease in Incidence Rate of Maternal Primary Cytomegalovirus Infection during the COVID-19 Pandemic in Japan.
| Content Provider | Europe PMC |
|---|---|
| Author | Toriyabe, Kuniaki Kitamura, Asa Hagimoto-Akasaka, Miki Ikejiri, Makoto Suga, Shigeru Kondo, Eiji Kihira, Masamichi Morikawa, Fumihiro Ikeda, Tomoaki |
| Editor | Nigro, Giovanni |
| Copyright Year | 2023 |
| Abstract | This study evaluated the impact of the coronavirus disease 2019 (COVID-19) pandemic on the occurrence of maternal primary cytomegalovirus (CMV) infection in Japan. We performed a nested case-control study using data from maternal CMV antibody screening under the Cytomegalovirus in Mother and infant-engaged Virus serology (CMieV) program in Mie, Japan. Pregnant women with negative IgG antibodies at ≤20 weeks of gestation who were retested at ≥28 weeks were enrolled. The study period was divided into 2015–2019 as the pre-pandemic and 2020–2022 as the pandemic period, and the study site included 26 institutions conducting the CMieV program. The incidence rate of maternal IgG seroconversion was compared between the pre-pandemic (7008 women enrolled) and pandemic (2020, 1283 women enrolled; 2021, 1100 women; and 2022, 398 women) periods. Sixty-one women in the pre-pandemic period and five, four, and five women during 2020, 2021, and 2022, respectively, showed IgG seroconversion. The incidence rates in 2020 and 2021 were lower (p < 0.05) than that in the pre-pandemic period. Our data suggest a transient decrease in the incidence of maternal primary CMV infection in Japan during the COVID-19 pandemic, which could be due to prevention and hygiene measures taken at the population level. |
| Journal | Viruses |
| Volume Number | 15 |
| PubMed Central reference number | PMC10222815 |
| Issue Number | 5 |
| PubMed reference number | 37243182 |
| e-ISSN | 19994915 |
| DOI | 10.3390/v15051096 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2023-04-29 |
| Access Restriction | Open |
| Rights License | Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). © 2023 by the authors. |
| Subject Keyword | primary cytomegalovirus infection pregnancy CMV screening congenital cytomegalovirus infection immunoglobulin G seroconversion SARS-CoV-2 COVID-19 pandemic |
| Content Type | Text |
| Resource Type | Article |
| Subject | Infectious Diseases Virology |
