NDLI: Transplacental transmission of SARS-CoV-2 immunoglobulin G antibody to infants from maternal COVID-19 vaccine immunization before pregnancy.

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Transplacental transmission of SARS-CoV-2 immunoglobulin G antibody to infants from maternal COVID-19 vaccine immunization before pregnancy.

Content Provider	Europe PMC
Author	Yang, Yuting Xing, Huiwu Zhao, Yao
Abstract	The coronavirus disease 2019 (COVID‐19) vaccine generates functional antibodies in maternal circulation that are detectable in infants, while the information is restricted to the usage of COVID‐19 vaccine during pregnancy. In this study, we aimed to evaluate the effect of maternal COVID‐19 vaccines before pregnancy. Infants were included from mothers with no inactivated COVID‐19 vaccine, 1‐, 2‐, and 3‐dose before pregnancy, and severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) immunoglobulin G (IgG) antibodies were tested. Comparative analysis was done between the groups. A total of 130 infants were enrolled in the study. Significantly higher levels of SARS‐CoV‐2 IgG antibodies in infants born to mothers with 3‐dose COVID‐19 vaccine before pregnancy compared with 1‐ and 2‐dose groups (p < 0.0001). The levels of antibodies decreased significantly with age in infants born to mothers with the 3‐dose COVID‐19 vaccine before pregnancy (r = −0.338, p = 0.035), and it was still higher than that 2‐dose COVID‐19 vaccine group. The maternal SARS‐CoV‐2 antibodies produced from the inactivated COVID‐19 vaccine before pregnancy can be transferred to newborns via the placenta. Maternal immunization with 3‐dose of the COVID‐19 vaccine before pregnancy could be more beneficial for both mothers and infants.
Page Count	6
ISSN	01466615
Journal	Journal of Medical Virology
Volume Number	95
PubMed Central reference number	PMC9877834
Issue Number	1
PubMed reference number	36367230
e-ISSN	10969071
DOI	10.1002/jmv.28296
Language	English
Publisher	John Wiley and Sons Inc.
Publisher Date	2022-11-18
Publisher Place	Hoboken
Access Restriction	Open
Rights License	This article is being made freely available through PubMed Central as part of the COVID-19 public health emergency response. It can be used for unrestricted research re-use and analysis in any form or by any means with acknowledgement of the original source, for the duration of the public health emergency. © 2022 Wiley Periodicals LLC.
Subject Keyword	coronavirus disease control SARS coronavirus virus classification vaccines/vaccine strains
Content Type	Text
Resource Type	Article
Subject	Infectious Diseases Virology

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