Loading...
Please wait, while we are loading the content...
Similar Documents
Profiling of chemical constituents of Matricarla chamomilla L. by UHPLC-Q-Orbitrap-HRMS and in vivo evaluation its anti-asthmatic activity.
| Content Provider | Europe PMC |
|---|---|
| Author | Li, Qian Abdulla, Rahima Xin, Xuelei Xue, Guipeng Kang, Xiaolong Zhao, Feicui Asia, Haji Akber |
| Copyright Year | 2023 |
| Abstract | Matricarla chamomilla L. is native to European countries and widely cultivated in China, especially in Xinjiang. It has been used in Uygur medicine for the treatment of cough caused by asthma. In this study, UHPLC-Q-Orbitrap-MS was used to detect and identify the components from the active fraction of M. Chamomile, 64 compounds were identified by combining the standards, related literatures and mass spectrometry fragments, including 10 caffeoyl quinic acids, 38 flavonoids, 8 coumarins, 5 alkaloids and 3 other compounds. Furtherly, the anti-asthma activity of active fraction of M. Chamomile was investigated in OVA-induced allergic asthma rat model. The results showed that the number of EOS in Penh and bronchoalveolar lavage fluid (BALF) in the group of the active fraction of M. Chamomile was significantly lower than that in the model group. Besides, the active fraction of M. Chamomile can significantly reduce the IgE level and increased glutathione peroxidase (GSH-Px) in the serum of OVA-induced rats, and ameliorated OVA-induced lung injury. Hence, M. Chamomile could be used to treat asthma through their in vivo antioxidant and anti-inflammatory effects. This study explored the potential material basis of M. Chamomile for the treatment of asthma. |
| Journal | Heliyon |
| Volume Number | 9 |
| PubMed Central reference number | PMC10160356 |
| Issue Number | 5 |
| PubMed reference number | 37153405 |
| e-ISSN | 24058440 |
| DOI | 10.1016/j.heliyon.2023.e15470 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2023-04-24 |
| Access Restriction | Open |
| Rights License | This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). © 2023 The Authors. Published by Elsevier Ltd. |
| Subject Keyword | Matricarla chamomilla L. Anti-asthmatic activity UHPLC Mass |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
