NDLI: <i>In Vivo</i> Antihypertensive Activity and UHPLC-Orbitrap-HRMS Profiling of <i>Cuphea ignea</i> A. DC.

Please wait, while we are loading the content...

In Vivo Antihypertensive Activity and UHPLC-Orbitrap-HRMS Profiling of Cuphea ignea A. DC.

Content Provider	Europe PMC
Author	Ismail, Walaa M. Ezzat, Shahira M. El-Mosallamy, Aliaa E.M.K. El Deeb, Kadriya S. El-Fishawy, Ahlam M.
Copyright Year	2022
Abstract	Cuphea ignea A. DC. isan ornamentaltropical plant belonging to the family Lythraceae. The aim of thisstudy is to verify the in vivo antihypertensive potentialof C. ignea A. DC. and to explore itsmetabolic profile using a UHPLC-Orbitrap-HRMS technique. The resultsrevealed that the ethanolic extract of the leaves in two doses (250and 500 mg/kg b.wt.) significantly normalized the elevated systolicblood pressure in N(G)-nitro-l-arginine-methyl ester-inducedhypertension in rats. An angiotensin-converting enzyme (ACE) concentrationwas significantly decreased by the high dose extract compared to lisinopril.Nitric oxide (NO) level was significantly restored by both doses.Concerning the oxidative stress parameters, both doses displayed significantreduction in malondialdehyde (MDA) level while the high dose restoredelevated glutathione level. These biochemical results were clearlysupported by the histopathological examination of the isolated heartand aorta. A UHPLC-Orbitrap-HRMS study was represented by a detailedmetabolic profile of leaves and flowers of C. ignea A. DC., where 53 compounds were identified among which flavonoids,fatty acids, and hydrolysable tannins were the major identified classes.This study established scientific evidence for the use of C. ignea A. DC., a member of genus Cuphea as a complementary treatment in the management of hypertension.
Journal	ACS Omega
Volume Number	7
PubMed Central reference number	PMC9773801
Issue Number	50
PubMed reference number	36570254
e-ISSN	24701343
DOI	10.1021/acsomega.2c05356
Language	English
Publisher	American Chemical Society
Publisher Date	2022-12-09
Access Restriction	Open
Rights License	Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/). © 2022 The Authors. Published by American Chemical Society
Content Type	Text
Resource Type	Article
Subject	Chemistry Chemical Engineering

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in