NDLI: Use of a Silkworm (<i>Bombyx mori</i>) Larvae By-Product for the Treatment of Atopic Dermatitis: Inhibition of NF-κB Nuclear Translocation and MAPK Signaling.

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Use of a Silkworm (Bombyx mori) Larvae By-Product for the Treatment of Atopic Dermatitis: Inhibition of NF-κB Nuclear Translocation and MAPK Signaling.

Content Provider	Europe PMC
Author	Fan, Meiqi Choi, Young-Jin Wedamulla, Nishala Erandi Zhang, Qun Kim, Seong Wan Bae, Sung Moon Seok, Young-Seek Kim, Eun-Kyung
Editor	Ferguson, Lynnette
Copyright Year	2023
Abstract	Atopic dermatitis (AD) is a long-lasting inflammatory skin disease that contributes to the global health burden and impacts 10–20% of the world’s population. In this study, we determined the anti-AD effect of a by-product of silkworm (Bombyx mori) larval powder, strain Yeonnokjam (SLPY), as a sustainable, natural source for the development of therapeutic agents for AD. HaCaT cells were used to assess the in vitro anti-inflammatory activity of SLPY, and a 1-chloro-2,4-dinitrobenzene (DNCB)-induced mouse model was used to study the in vivo anti-AD effects. SLPY treatment downregulated the expression of the inflammatory cytokines TNF-α, IL1β, IL-8, and Cox-2 in stimulated HaCaT cells. Similarly, the topical application of SLPY in DNCB-treated mice downregulated the expression of inflammatory cytokines and proteins while ameliorating the clinical features of AD. Further, SLPY treatment inhibited the nuclear translocation of NF-κb p65, thereby supporting the efficacy of SLPY in the treatment of AD.
Journal	Nutrients
Volume Number	15
PubMed Central reference number	PMC10097122
Issue Number	7
PubMed reference number	37049614
e-ISSN	20726643
DOI	10.3390/nu15071775
Language	English
Publisher	MDPI
Publisher Date	2023-04-05
Access Restriction	Open
Rights License	Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). © 2023 by the authors.
Subject Keyword	atopic dermatitis Bombyx mori Yeonnokjam silkworm by-product NF-κB p65
Content Type	Text
Resource Type	Article
Subject	Food Science Nutrition and Dietetics

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