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Age- and sex-related features of atherosclerosis from coronary computed tomography angiography in patients prior to acute coronary syndrome: results from the ICONIC study
| Content Provider | eScholarship Repository: University of California |
|---|---|
| Author | Conte, Edoardo Dwivedi, Aeshita Mushtaq, Saima Pontone, Gianluca Lin, Fay Y Hollenberg, Emma J Lee, Sang-Eun Bax, Jeroen Cademartiri, Filippo Chinnaiyan, Kavitha Chow, Benjamin JW Cury, Ricardo C Feuchtner, Gudrun Hadamitzky, Martin Kim, Yong-Jin Baggiano, Andrea Leipsic, Jonathon Maffei, Erica Marques, Hugo Plank, Fabian Raff, Gilbert L van Rosendael, Alexander R Villines, Todd C Weirich, Harald G Al’Aref, Subhi J Baskaran, Lohendran Cho, Iksung Danad, Ibrahim Han, Donghee Heo, Ran Lee, Ji Hyun Stuijfzand, Wijnand J Gransar, Heidi Lu, Yao Sung, Ji Min Park, Hyung-Bok Al-Mallah, Mouaz H de Araújo Gonçalves, Pedro Berman, Daniel S Budoff, Matthew J Samady, Habib Shaw, Leslee J Stone, Peter H Virmani, Renu Narula, Jagat Min, James K Chang, Hyuk-Jae Andreini, Daniele |
| Abstract | AimsAlthough there is increasing evidence supporting coronary atherosclerosis evaluation by coronary computed tomography angiography (CCTA), no data are available on age and sex differences for quantitative plaque features. The aim of this study was to investigate sex and age differences in both qualitative and quantitative atherosclerotic features from CCTA prior to acute coronary syndrome (ACS).Methods and resultsWithin the ICONIC study, in which 234 patients with subsequent ACS were propensity matched 1:1 with 234 non-event controls, our current subanalysis included only the ACS cases. Both qualitative and quantitative advance plaque analysis by CCTA were performed by a core laboratory. In 129 cases, culprit lesions identified by invasive coronary angiography at the time of ACS were co-registered to baseline CCTA precursor lesions. The study population was then divided into subgroups according to sex and age (<65 vs. ≥ 65 years old) for analysis. Older patients had higher total plaque volume than younger patients. Within specific subtypes of plaque volume, however, only calcified plaque volume was higher in older patients (135.9 ± 163.7 vs. 63.8 ± 94.2 mm3, P < 0.0001, respectively). Although no sex-related differences were recorded for calcified plaque volume, females had lower fibrous and fibrofatty plaque volume than males (Fibrofatty volume 29.6 ± 44.1 vs. 75.3 ± 98.6 mm3, P = 0.0001, respectively). No sex-related differences in the prevalence of qualitative high-risk plaque features were found, even after separate analyses considering age were performed.ConclusionOur data underline the importance of age- and sex-related differences in coronary atherosclerosis presentation, which should be considered during CCTA-based atherosclerosis quantification. |
| File Format | |
| DOI | 10.1093/ehjci/jeaa210 |
| Alternate Webpage(s) | https://escholarship.org/uc/item/7638v2qf |
| Journal | European Heart Journal - Cardiovascular Imaging |
| Issue Number | 1 |
| Volume Number | 22 |
| Language | English |
| Publisher Date | 2021-01-01 |
| Access Restriction | Open |
| Subject Keyword | Gender Medicine High-Risk Plaque Features Biomedical and Clinical Sciences Clinical Sciences Heart Disease Atherosclerosis Biomedical Imaging Aging Clinical Research Heart Disease - Coronary Heart Disease Cardiovascular Acute Coronary Syndrome Aged Computed Tomography Angiography Coronary Angiography Coronary Artery Disease Female Humans Male Plaque Atherosclerotic cardiac CT CCTA Cardiovascular medicine and haematology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cardiology and Cardiovascular Medicine Radiology, Nuclear Medicine and Imaging |
