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Longitudinal quantitative assessment of coronary atherosclerosis related to normal systolic blood pressure maintenance in the absence of established cardiovascular disease
| Content Provider | eScholarship Repository: University of California |
|---|---|
| Author | Won, Ki‐Bum Park, Hyung‐Bok Heo, Ran Lee, Byoung Kwon Lin, Fay Y Hadamitzky, Martin Kim, Yong‐Jin Sung, Ji Min Conte, Edoardo Andreini, Daniele Pontone, Gianluca Budoff, Matthew J Gottlieb, Ilan Chun, Eun Ju Cademartiri, Filippo Maffei, Erica Marques, Hugo de Araújo Gonçalves, Pedro Leipsic, Jonathon A Lee, Sang‐Eun Shin, Sanghoon Choi, Jung Hyun Virmani, Renu Samady, Habib Chinnaiyan, Kavitha Berman, Daniel S Narula, Jagat Bax, Jeroen J Min, James K Chang, Hyuk‐Jae |
| Abstract | BackgroundAtherosclerosis-related adverse events are commonly observed even in conditions with low cardiovascular (CV) risk. Longitudinal data regarding the association of normal systolic blood pressure maintenance (SBPmaintain ) with coronary plaque volume changes (PVC) has been limited in adults without traditional CV disease.HypothesisNormal SBPmaintain is important to attenuate coronary atherosclerosis progression in adults without baseline CV disease.MethodsWe analyzed 95 adults (56.7 ± 8.5 years; 40.0% men) without baseline CV disease who underwent serial coronary computed tomographic angiography with mean 3.5 years of follow-up. All participants were divided into two groups of normal SBPmaintain (follow-up SBP < 120 mm Hg) and ≥elevated SBPmaintain (follow-up SBP ≥ 120 mm Hg). Annualized PVC was defined as PVC divided by the interscan period.ResultsCompared to participants with normal SBPmaintain , those with ≥elevated SBPmaintain had higher annualized total PVC (mm3 /year) (0.0 [0.0-2.2] vs. 4.1 [0.0-13.0]; p < .001). Baseline total plaque volume (β = .10) and the levels of SBPmaintain (β = .23) and follow-up high-density lipoprotein cholesterol (β = -0.28) were associated with annualized total PVC (all p < .05). The optimal cutoff of SBPmaintain for predicting plaque progression was 118.5 mm Hg (sensitivity: 78.2%, specificity: 62.5%; area under curve: 0.700; 95% confidence interval [CI]: 0.59-0.81; p < .05). SBPmaintain ≥ 118.5 mm Hg (odds ratio [OR]: 4.03; 95% CI: 1.51-10.75) and baseline total plaque volume (OR: 1.03; 95% CI: 1.01-1.06) independently influenced coronary plaque progression (all p < .05).ConclusionNormal SBPmaintain is substantial to attenuate coronary atherosclerosis progression in conditions without established CV disease. |
| File Format | |
| ISSN | 01609289 |
| DOI | 10.1002/clc.23870 |
| Alternate Webpage(s) | https://escholarship.org/uc/item/0737r339 |
| Journal | Clinical Cardiology |
| Issue Number | 8 |
| Volume Number | 45 |
| Language | English |
| Publisher Date | 2022-08-01 |
| Access Restriction | Open |
| Rights License | https://creativecommons.org/licenses/by/4.0/ |
| Subject Keyword | Coronary Computed Tomography Angiography Systolic Blood Pressure Biomedical and Clinical Sciences Clinical Sciences Clinical Research Atherosclerosis Heart Disease - Coronary Heart Disease Heart Disease Cardiovascular Aging Good Health and Well Being Female Humans Male Blood Pressure Cardiovascular Diseases Computed Tomography Angiography Coronary Angiography Coronary Artery Disease Disease Progression Plaque Atherosclerotic Risk Factors Cardiorespiratory Medicine and Haematology Cardiovascular System & Hematology Cardiovascular medicine and haematology |
| Content Type | Text |
| Resource Type | Article |
